ID W5NQN7_SHEEP Unreviewed; 519 AA.
AC W5NQN7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
GN Name=ADGRG5 {ECO:0000313|Ensembl:ENSOARP00000000477.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000477.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000000477.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000477.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000000477.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMGL01027917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01027918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01027919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01027920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NQN7; -.
DR SMR; W5NQN7; -.
DR STRING; 9940.ENSOARP00000000477; -.
DR PaxDb; 9940-ENSOARP00000000477; -.
DR Ensembl; ENSOART00000000505.1; ENSOARP00000000477.1; ENSOARG00000000473.1.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_002753_3_9_1; -.
DR OMA; RIHVNLH; -.
DR Proteomes; UP000002356; Chromosome 14.
DR Bgee; ENSOARG00000000473; Expressed in leukocyte and 38 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR003910; GPR1/GPR3/GPR5.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF326; ADHESION G-PROTEIN COUPLED RECEPTOR G5; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01422; GPR56ORPHANR.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..519
FT /note="G-protein coupled receptors family 2 profile 2
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868189"
FT TRANSMEM 244..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 244..498
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 519 AA; 57905 MW; 4CC6AB5F51CCCB6C CRC64;
MDCCWAPFLY LCLLASQSRM AEASQETLDW MKRMEAAAKR RSNTSFAELV HGLELRLLNA
SFGGHNLTLQ THIIQALAFK LNCNFTGLSL SSAAVEKVPQ AQPQHAMQFP AELTQNACRT
RSGDLRLICI YFSSTRFFQK DINSSLLSNY VLGAQLNHGY VSNLSEPVNI SFWHNQSLEG
YTVTCVFWKE RASKHQWGAW SPEGCRTERP TPSQVLCRCN HLTYFAVLMQ ISQAPIPAEL
LAPLTYISLV GCSISIVASL LTVLLHVQAR KQSDSVTRIH MNLHASVLLL NIAFLLSPVL
ATPPVPGAAC VALAATLHYA LLSCLTWMAI EGFNLYLLLG RVYNIYIRRY VLKLCAVGWG
VPAFLVLLLL AIKSSVYGPC RIQLSDSQGN STGFKTMSMC WVQSPWVHRV LVMGYGGLTS
LFNLVVLAWA LRVLNKLRAQ EKAARDAVTV LGLTVLLGTT WALAFFSFSV FLLPQLFLFT
IFNSLYGFFL FLWFCSQRCR SEAEAEAEME VFTSSQMVQ
//
