ID W5NRU2_SHEEP Unreviewed; 1142 AA.
AC W5NRU2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Adhesion G protein-coupled receptor A2 {ECO:0008006|Google:ProtNLM};
GN Name=ADGRA2 {ECO:0000313|Ensembl:ENSOARP00000000882.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000882.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000000882.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000882.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000000882.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; AMGL01073272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01073273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01073274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01073275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01073276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01073277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01073278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01073279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01073280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NRU2; -.
DR SMR; W5NRU2; -.
DR STRING; 9940.ENSOARP00000000882; -.
DR PaxDb; 9940-ENSOARP00000000882; -.
DR Ensembl; ENSOART00000000915.1; ENSOARP00000000882.1; ENSOARG00000000851.1.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_005242_0_0_1; -.
DR OMA; CAEDRPK; -.
DR Proteomes; UP000002356; Chromosome 26.
DR Bgee; ENSOARG00000000851; Expressed in vas deferens and 51 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF1; ADHESION G PROTEIN-COUPLED RECEPTOR A2; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 759..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 874..894
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1006..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1032..1053
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 263..350
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 756..931
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1142 AA; 122487 MW; 515180C98FC8E1B0 CRC64;
SGVRGSRASA TPKRGTKFIP TQGHLWSSPR ETRGAPGCPV PIRSCKCSGE RPKGLSGGAP
NPARRRVACG GGDLPEPPDP GLLPNSTVTL LLSNNKITGL RSRAFLGLSL LEKLDLNHCT
AARSTVQPGA FLGLGELKRL DLSNNRIGCL TSGTFQGRRG WRVGNISGNI FSSLQPGVFD
ELPALKVVDF GTEFLTCDCR LSWLLPWARN RSLQLSERTL CAYPSALHAQ ALAGLQEAQL
RCEGALELHT LHLIPSLRQV VFQGDRLPFQ CSASYLGNDT RIRWYHNRAP VEGDEQAGQA
GVLLADSLVH DCTFITSELT LSHIGVWASG EWECSVSTVQ GNASKKVEIV VLETSASYCP
AERVANNRGD FRWPRTLAGI TAYQSCLQYP FTSVPLRRGR AGRWEPGDYS HCLYTNDITR
VLYTFVLMPI NASNALTLAH QLRVYTAEAA SFSDMMDVVY VAQMIQKFLG YVDQIKELVE
VMVDMASNLM LVDEHLLWLA QREDKACSGI VGALERIGGA ALSAHAQHIS VNSRNVALEA
YLIKPHSYVG LTCTAFQRRE AGMPGTRPAG PGQSPSPEPE PLADQQLRFR CTTGRPNVSL
SAFHIKLPPA WASLSSPSSP GASCPRRVPA LLYPPFTLAL APSVSPSPFL SPTPESSLPS
QVTTPFLANL GGCGVGNLTE PVAVSLRHWA EGAEPVAAWW SQEGPGGPGG WRSEGCQLRS
SQPNVSSLHC QHLGNVAVLM ELSAFPREAG GSGAGLHPVV YPCTALLLLC LFSTIITYIL
NHSSIHVSRK GWHMLLNLCF HMAMTSAVFA GGITLTNYQM VCQAVGITLH YSSLSTLLWM
GVKARVLHKE LTWRAPPPPE GDAAPPAPRP MLRFYLIAGG IPLIICGITA AVNIHNYRDH
SPYCWLVWRP SLGAFYIPVA LILLITWIYF LCAGLRLRGP LAQSPKGGTG RVSLEPREDL
RGSTRLRSSG PLLSDSGSLL AAGSTGMVTP GPPEDGDGLY SPGVQLGALV TTHFLYLATW
ACGALTVSQR WLPRVVCSCL YGVAASALGL FVFPHHCARR RDVRASWRAC RPPPSGSRAS
PRAVPAGPED GSPVFGEGPP SLKSSPSGSS GHAPPPGPCK LTNLQLAQSQ ACEAEAAARG
GG
//
