ID W5NS41_SHEEP Unreviewed; 468 AA.
AC W5NS41;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=TRIM21 {ECO:0000313|Ensembl:ENSOARP00000000981.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000981.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000000981.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000981.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000000981.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC {ECO:0000256|ARBA:ARBA00008518}.
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DR EMBL; AMGL01032317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01032318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NS41; -.
DR SMR; W5NS41; -.
DR STRING; 9940.ENSOARP00000000981; -.
DR PaxDb; 9940-ENSOARP00000000981; -.
DR Ensembl; ENSOART00000001014.1; ENSOARP00000000981.1; ENSOARG00000000944.1.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_013137_0_3_1; -.
DR OMA; CRNSVQR; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000000944; Expressed in major salivary gland and 51 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19772; Bbox2_TRIM21_C-IV; 1.
DR CDD; cd16596; RING-HC_TRIM21_C-IV; 1.
DR CDD; cd12900; SPRY_PRY_TRIM21; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR035831; PRY/SPRY_TRIM21.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR020457; Znf_B-box_chordata.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF46; E3 UBIQUITIN-PROTEIN LIGASE TRIM21; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01406; BBOXZNFINGER.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 19..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 90..131
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 271..468
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 135..162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 186..245
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 468 AA; 53701 MW; 41732DE9DF2701FA CRC64;
ITPMASAVPL TMMWEEVTCS ICLDPMVEPM SIECGHSFCQ ECISEVGKEG GSVCPVCRRH
FLLQNLRPNR QVANMVDNLR KISQGAKEGP HGELCVVHRE KIHLFCEADG KALCWVCSQS
QKHRDHPMVP IEEAAQEYQE KLQVALKKLR DKQEMAEKLE LDIAMKKASF KGKVEAQKLR
IHEEFIRQKN FLAEEEQKQL QKLEEEERQQ LRTLGDTEAR LAQQIQALQE LIAEVERRRR
GSALELLQEV KSVLERSESW NLKEVDVAST DLRNVFYVPG IKKMLRTCGV HITLDPQTAN
PWLILSENRR QVRLANTRQD VPENEERFDT YPMVLGAQRF DSGKVYWEVD VTGKEAWDLG
VCRDNVRRKG QFLLNSDNGF WIIWLWNKQK YEAGTCPQTP LHLQVPPSQI GIFLDYEAST
VSFYNITDHG SLIYTFSECA FAGPLRPFFN PGFNDRGKNS APLILCPL
//
