ID W5NTL6_SHEEP Unreviewed; 821 AA.
AC W5NTL6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=E3 ubiquitin-protein ligase HECTD3 {ECO:0008006|Google:ProtNLM};
GN Name=HECTD3 {ECO:0000313|Ensembl:ENSOARP00000001508.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001508.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000001508.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001508.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000001508.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01001186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01001187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000001508; -.
DR PaxDb; 9940-ENSOARP00000001508; -.
DR Ensembl; ENSOART00000001551.1; ENSOARP00000001508.1; ENSOARG00000001446.1.
DR eggNOG; KOG0939; Eukaryota.
DR eggNOG; KOG1426; Eukaryota.
DR HOGENOM; CLU_002173_11_0_1; -.
DR OMA; PAWDYTL; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000001446; Expressed in gastric lymph node and 55 other cell types or tissues.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd08666; APC10-HECTD3; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 181..359
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 474..817
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 783
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 821 AA; 92890 MW; E402EABD25E58CE0 CRC64;
MAGPGPGAAL ESPRQLLGRV RFLAEAAKSL RAGRPLPAAL AFVPREVLYK LYKDPAGPSR
VLLPVXAGRA AGSSLTAVVV WCSRQEQLAE HLGDCGLDEG WLLVCRPAEG GARLVPIDTP
DHLQRQQQLF GVDYRPVLRW EQVVDLTYSH RLGSRPQPAE AYTEAVQRLL YVPPTWTYEC
DEDLIHFLYD HLGKEDENLG SVKQYVESID VSSYTEEFNV SCLTDSNADT YWESDGSQCQ
HWVRLTMKKG TIVKKLLLTV DTTDDNFMPK RVVVYGGEGD NLKKLSDVSI DETLIGDVCV
LEDMTVHLPI IEIRIVECRD DGIDVRLRGV KIKSSRQREL GLNADLFQPT NLVRYPRLEG
TDPEVLYRRA VLLQRFIKIL DSVLHHLVPA WDHTLGTFSE IKQVKQFLLL SRQRPGLVAQ
CLRDSESSKP SFMPRLYINR RLAMEHRACP LRDPACKNAV FTQVYEGLKP SDKYEKPLDY
RWPMRYDQWW ECKFIAEGII DQGGGFRDSL ADMSEELCPS SADTPVPLPF FVRTANQGNG
TGEARDMYVP NPSCRDFAKY EWIGQLMGAA LRGKEFLVLA LPGFVWKQLS GEEVSWSKDF
PAVDSVLVKL LEVMEGMDKE TFEFKFGKEL TFTTVLSDQQ VVELIPGGSG IVVGYEDRSR
FIQLVQKARL EESKEQVAAM QAGLLKVVPQ AVLDLLTWQE LEKKVCGDPE VTVDALRKLT
RFEDFEPSDT RVQYFWEALN NFTNEDRSRF LRFVTGPSRP PAHIYPDKLG YETTDALPES
STCSSTLFLP HYASAKVCEE KLRYAAYNCV AIDTDMSPWE E
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