ID   W5NTZ2_SHEEP            Unreviewed;       678 AA.
AC   W5NTZ2; A0A6P3TGB1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Pyrin {ECO:0008006|Google:ProtNLM};
GN   Name=LOC101121821 {ECO:0000313|Ensembl:ENSOARP00000001636.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001636.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000001636.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001636.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000001636.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AMGL01068088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011959405.1; XM_012104015.2.
DR   AlphaFoldDB; W5NTZ2; -.
DR   Ensembl; ENSOART00000001679.1; ENSOARP00000001636.1; ENSOARG00000001557.1.
DR   HOGENOM; CLU_016050_0_0_1; -.
DR   Proteomes; UP000002356; Chromosome 24.
DR   Bgee; ENSOARG00000001557; Expressed in leukocyte and 25 other cell types or tissues.
DR   ExpressionAtlas; W5NTZ2; baseline.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08321; Pyrin_ASC-like; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000315; Znf_B-box.
DR   PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR   PANTHER; PTHR24103:SF606; PYRIN; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
SQ   SEQUENCE   678 AA;  75125 MW;  8F771AF2B59BB900 CRC64;
     MVRTRSDHLL YSLEELLPYD FEKFKFKLQN TSLEKEHTRI PRGQLQTAEP VKLASLLVNH
     YGEEYAVQLT LQVLRAINQH LLAEELHQLI SPVCRIQEGD TDSSATSGSS GEMKPKSLKT
     LDGLEGDKQR QSADGAGCPS SSQPEAGRGS QKKPLGKQRD QKGPEGLEVQ SKLGARNTTL
     SSKRSPFLGK VLREKEKGSC PSVRLRRNAS SAGRLQGLTS GSLAGSPGRR ETKISEVYLP
     SGKKRPKSLE FTISPEETGP LNPEILLLQE KMNTENPSSA TTASEVATLK TGPTVTLEKG
     SRNPEHATTL EGTALRNTPF SVPLAGKTMI GEHLEPKAPA ERSGTGAPKA SSVPHEPSDP
     EVSPSSGRLQ DKAVCPLCRA QEGDPAGGSC VHISCSCSSA SGDPEASLSR SSSCPRCQDL
     LPGKGHGSRE WQEGLQMASL NPKSLPQCER HMKQAQLLFC EDHGELICLI CRLSQEHRGH
     RVRPIEEAAL EYKEQIQKQL DHLKELRKSG EEQRSQEDKK TVNSLKQAET QKQRIQYQLE
     QLCQFLEQQE RLFVAWLEEL GQTIGQVRET YGTRGTRDIA LLDELIGELE AKQCQPEWEL
     MKDIGVTLHR AKMVTVPELW ATPPEVKEKI HLLYQKSAFV EKRVKHFLET LRSEVETFNV
     NVILEAETVH SNLIFHLL
//