ID W5NUA4_SHEEP Unreviewed; 298 AA.
AC W5NUA4; A0A6P3ECQ5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=tRNA-uridine aminocarboxypropyltransferase {ECO:0000256|ARBA:ARBA00012386};
DE EC=2.5.1.25 {ECO:0000256|ARBA:ARBA00012386};
GN Name=DTWD2 {ECO:0000313|Ensembl:ENSOARP00000001748.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000001748.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000001748.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000001748.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000001748.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-
CC amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-
CC thioadenosine; Xref=Rhea:RHEA:62432, Rhea:RHEA-COMP:13339, Rhea:RHEA-
CC COMP:16092, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:65315, ChEBI:CHEBI:82930; EC=2.5.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00024168};
CC -!- SIMILARITY: Belongs to the TDD superfamily. DTWD2 family.
CC {ECO:0000256|ARBA:ARBA00034489}.
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DR EMBL; AMGL01092281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01092282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01092283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01092284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01092285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01092286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004008740.1; XM_004008691.3.
DR AlphaFoldDB; W5NUA4; -.
DR STRING; 9940.ENSOARP00000001748; -.
DR PaxDb; 9940-ENSOARP00000001748; -.
DR Ensembl; ENSOART00000001791.1; ENSOARP00000001748.1; ENSOARG00000001662.1.
DR GeneID; 101115791; -.
DR KEGG; oas:101115791; -.
DR CTD; 285605; -.
DR eggNOG; KOG4382; Eukaryota.
DR HOGENOM; CLU_066458_3_0_1; -.
DR OMA; GTWRKAF; -.
DR OrthoDB; 197144at2759; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000001662; Expressed in gastric lymph node and 55 other cell types or tissues.
DR GO; GO:0016432; F:tRNA-uridine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006400; P:tRNA modification; IEA:Ensembl.
DR InterPro; IPR005636; DTW.
DR InterPro; IPR039262; DTWD2/TAPT.
DR PANTHER; PTHR21392:SF0; TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2; 1.
DR PANTHER; PTHR21392; UNCHARACTERIZED; 1.
DR Pfam; PF03942; DTW; 1.
DR SMART; SM01144; DTW; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
SQ SEQUENCE 298 AA; 33475 MW; 56D3188CECEE8ECE CRC64;
MEQHQEARTP GDPVAWPPGT LRSQTPEEEE PRVGGSAPAA SVLDAEAYGA SADGLWELPV
EPAERRPECS HCSRPQKVCL CPFLPAHPLH ISTYLYIIQH PAEENKVLRT VPLLAACLPK
DKCKIKIGRR FSEERDPELS TICRKSDTLI LYPGAEAASL EEFILDSPVY PSTIIIIDGT
WSQAKDIFYK NSLFRLPKQV QLKTSISSQY VIRAQPTNRC LSTLECAAVA LSILEKNNYI
QETLLRPLQA LCSFQLQHGA QIRLSKEHLL KNGLYPKPMP KNKRKLRKME LLMNSVKI
//
