ID W5NV23_SHEEP Unreviewed; 404 AA.
AC W5NV23;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Cytohesin 3 {ECO:0008006|Google:ProtNLM};
GN Name=CYTH3 {ECO:0000313|Ensembl:ENSOARP00000002018.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002018.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002018.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002018.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002018.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01069567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01069568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01069569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01069570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NV23; -.
DR SMR; W5NV23; -.
DR STRING; 9940.ENSOARP00000002018; -.
DR PaxDb; 9940-ENSOARP00000002018; -.
DR Ensembl; ENSOART00000002065.1; ENSOARP00000002018.1; ENSOARG00000001922.1.
DR eggNOG; KOG0930; Eukaryota.
DR HOGENOM; CLU_032820_3_0_1; -.
DR OMA; TSHMEAQ; -.
DR Proteomes; UP000002356; Chromosome 24.
DR Bgee; ENSOARG00000001922; Expressed in aortic valve and 53 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF320; CYTOHESIN-3; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 57..148
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 262..385
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 22..56
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 404 AA; 46147 MW; ED62184E8DDB179B CRC64;
YFLSGDSVSV PEDLSLEERE ELLDIRRRKK ELIDDIERLK YEIAEVMTEI DNLTSVEESK
TTQRNKQIAM GRKKFNMDPK KGIQFLIEND LLQSSPEDVA QFLYKGEGLN KTVIGDYLGE
RDEFNIKVLQ AFVELHEFAD LNLVQALRWG GPLLPPRGPG SGSAPCCFAF SLFAWSSAVV
GDPLPTSGCG LSAWAHFSPH LALPTSHMEA QGVPRRVWVL CPGGRPGPGS QPRWQVLHES
RKNEPFKIPE DDGNDLTHTF FNPDREGWLL KLGERRRGAG GRVKTWKRRW FILTDNCLYY
FEYTTDKEPR GIIPLENLSI REVEDPRKPN CFELYNPSHK GQVIKACKTE ADGRVVEGNH
VVYRISAPSP EEKEEWMKSI RASISRDPFY DMLATRKRRI ANKK
//
