ID W5NW13_SHEEP Unreviewed; 357 AA.
AC W5NW13;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Apolipoprotein A-V {ECO:0000256|ARBA:ARBA00040758};
DE AltName: Full=Apolipoprotein A5 {ECO:0000256|ARBA:ARBA00042594};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002359.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002359.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002359.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002359.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with GPIHBP1 (By similarity). Interacts with SORL1;
CC this interaction leads to APOA5 internalization and sorting either to
CC lysosomes and degradation, or to the trans-Golgi network.
CC {ECO:0000256|ARBA:ARBA00038829}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}. Late endosome
CC {ECO:0000256|ARBA:ARBA00004603}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000256|ARBA:ARBA00008788}.
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DR EMBL; AMGL01031431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NW13; -.
DR SMR; W5NW13; -.
DR STRING; 9940.ENSOARP00000002359; -.
DR PaxDb; 9940-ENSOARP00000002359; -.
DR Ensembl; ENSOART00000002410.1; ENSOARP00000002359.1; ENSOARG00000002233.1.
DR eggNOG; ENOG502S33P; Eukaryota.
DR HOGENOM; CLU_747959_0_0_1; -.
DR OMA; HERVGWN; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000002233; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 1.20.120.20; Apolipoprotein; 1.
DR Gene3D; 1.20.5.1230; Apolipoprotein A-I; 1.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF13; APOLIPOPROTEIN A-V; 1.
DR Pfam; PF01442; Apolipoprotein; 1.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; HDL {ECO:0000256|ARBA:ARBA00022850};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..357
FT /note="Apolipoprotein A-V"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868111"
FT REGION 34..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 233..260
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 42..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 39854 MW; 3F970CC74404E541 CRC64;
MASAAAVLTW ALALLSLLSA TDARKGFWDY FSQSSGDKGK VEQQQKLARE PPRREKTPEG
GMAASARFLN LPVLPGKQSG ASSAGYPGGP VSPEDQRAAS LEQRSLKDRL EPDLSDMDKF
LEKLQLQPYT VELMEQVALR VHELQEQLRV VGEGTKAQLL GGVDEARGLL QELQNRVAHH
TGRVKALFHP YAERLVSGIG HHVQELHRSV APHAIASPER LSRCVQMLSR KLTLKAKALH
ERIQQNLDQL REELSAFAGA RADDAEEAAQ PDPQVLSQEV RQRLQAFRQD TFRQIAAFTH
AIDRETEQVQ QHPRPPPPGH SAFTEKARSE LQARFDDLWE DINYSLRDHS PGHRGEP
//
