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Database: UniProt
Entry: W5NWP7_SHEEP
LinkDB: W5NWP7_SHEEP
Original site: W5NWP7_SHEEP 
ID   W5NWP7_SHEEP            Unreviewed;       348 AA.
AC   W5NWP7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=Caspase-14 {ECO:0000313|Ensembl:ENSOARP00000002594.1};
GN   Name=LOC780455 {ECO:0000313|Ensembl:ENSOARP00000002594.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002594.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000002594.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002594.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000002594.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   EMBL; AMGL01044320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01044321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01044322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01044323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5NWP7; -.
DR   STRING; 9940.ENSOARP00000002594; -.
DR   PaxDb; 9940-ENSOARP00000002594; -.
DR   Ensembl; ENSOART00000002647.1; ENSOARP00000002594.1; ENSOARG00000002441.1.
DR   eggNOG; KOG3573; Eukaryota.
DR   HOGENOM; CLU_707804_0_0_1; -.
DR   OMA; TSCIDPD; -.
DR   Proteomes; UP000002356; Chromosome 19.
DR   Bgee; ENSOARG00000002441; Expressed in popliteal lymph node and 52 other cell types or tissues.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR22576:SF42; CASPASE 23, APOPTOSIS-RELATED CYSTEINE PEPTIDASE; 1.
DR   PANTHER; PTHR22576; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN          134..241
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          260..348
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
SQ   SEQUENCE   348 AA;  40128 MW;  4E53CB21B3F48A01 CRC64;
     KISPATEELQ SRLQETLDLL SSQELRSFRD HLKKVEPRVS QLKLELEGKT PSGLAKLLAK
     HYYPPAVANG VLVQVLRLLP RADLLPRWQS APTDCPVIPR KSLKRSYDCV DGELYRYDLS
     GKRKAFLMCV KKNRPGAHQD VLLMKNWLNE CKFEETLCID PDKMDLLEKI TSFRDELNEI
     KDNIGCCLVT LMSHGEEGFI KMKDGEKVSL EDIFEMFNNK NCPALQEKPK IFIIQACRGE
     RRDSGVETDD EPMDLDDGSE KKRLPTFSDY FIIYPTQADH VALRDPRTGS VMIKEMTEVF
     KQYGNKWHLA DFFTIVNNRV VHRDFSLCNK PVKISLVMES TLTKFVYF
//
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