ID W5NWX8_SHEEP Unreviewed; 393 AA.
AC W5NWX8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000002675.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002675.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002675.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002675.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002675.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC {ECO:0000256|ARBA:ARBA00005733}.
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DR EMBL; AMGL01001261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NWX8; -.
DR SMR; W5NWX8; -.
DR STRING; 9940.ENSOARP00000002675; -.
DR PaxDb; 9940-ENSOARP00000002675; -.
DR Ensembl; ENSOART00000002728.1; ENSOARP00000002675.1; ENSOARG00000002517.1.
DR eggNOG; KOG0490; Eukaryota.
DR HOGENOM; CLU_060969_0_0_1; -.
DR OMA; NSLNAMY; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000002517; Expressed in conceptus and 2 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR46639; DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1; 1.
DR PANTHER; PTHR46639:SF2; DIENCEPHALON_MESENCEPHALON HOMEOBOX PROTEIN 1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 69..119
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 370..383
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 71..120
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 189..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 41936 MW; 35B9AFB2B51B80D1 CRC64;
QAHAAMQHYG VNGYSLHAMN SLSAMYNLHQ QAAQQAQHAP DYRPSVHALT LAERLADIIL
EARYGSQHRK QRRSRTAFTA QQLEALEKTF QKTHYPDVVM RERLAMCTNL PEARVQGWFP
TVQEPTFQTA PGVSMNDCSD RRGVGEGIVG ACFPEDPWGV PCSKTPLCPL HSCSPSPCPQ
VWFKNRRAKF REQSASESAP EDQPDREEDP QAGAEDPKTE KSPGAEREGT GLRAGGEGEP
QTDSPGSLAL PPAAPGAGLL GPSHSYSSSP LSLFRLQEQF RQHMAATSNL VHYSSFEVGG
PAPAAAAAAA AAVPYLGVNV APLGSLHCQS YYQSLSAAAA AHQGVWGSPL LPAPPAGLAP
ASAALNSKTT SIENLRLRAK QHAASLGLDT LPN
//
