ID W5NX80_SHEEP Unreviewed; 337 AA.
AC W5NX80;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002777.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002777.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Antigen-presenting protein that binds self and non-self lipid
CC and glycolipid antigens and presents them to T-cell receptors on
CC natural killer T-cells. {ECO:0000256|ARBA:ARBA00037203}.
CC -!- SUBUNIT: Heterodimer with B2M (beta-2-microglobulin). Interacts with
CC saposin C. {ECO:0000256|ARBA:ARBA00038793}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR AlphaFoldDB; W5NX80; -.
DR SMR; W5NX80; -.
DR STRING; 9940.ENSOARP00000002777; -.
DR PaxDb; 9940-ENSOARP00000002777; -.
DR Ensembl; ENSOART00000002832.1; ENSOARP00000002777.1; ENSOARG00000002614.1.
DR eggNOG; ENOG502SJH6; Eukaryota.
DR HOGENOM; CLU_047501_9_2_1; -.
DR OMA; ADCERHS; -.
DR Proteomes; UP000002356; Unplaced.
DR Bgee; ENSOARG00000002614; Expressed in thymus and 6 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd21029; IgC1_CD1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR PANTHER; PTHR16675:SF130; T-CELL SURFACE GLYCOPROTEIN CD1B; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF16497; MHC_I_3; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..337
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868333"
FT TRANSMEM 298..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..291
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 337 AA; 37829 MW; 4920F148E8F67428 CRC64;
MLLLPLLLLV FIIPGRNHEG VFQEPTAFYL NQISTYAKST WSNQGLGWLD DLQIHDWESD
SYTAIFLKPR CKSNFSDEEM TELEDLFRIY FIGFTQEVQD HISEFSLEYP FGIQVIESCG
LHSGKAIGSS LRGVLGGLDF VRIQNHSCVP APDSGSRRQK FCALKTQYQS ISNVIEKLMS
ETCPRYLGVL DAVKAELQRQ VKPEAWMSSG PISVPGLLLV CHVSGFYPKP VQVMWMRGEQ
EQPGTQQGDI MPNADWTWYL RVTLDVAAGE AAGLSCRVKH SSLGDQNIIL NLECSTSIGL
ILVAIILPSL ILLICLMVWE VLQFFACVLN RSYQNIL
//