ID W5NXI9_SHEEP Unreviewed; 315 AA.
AC W5NXI9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein {ECO:0000256|ARBA:ARBA00015474};
GN Name=TRADD {ECO:0000313|Ensembl:ENSOARP00000002886.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002886.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002886.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002886.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01028278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NXI9; -.
DR Ensembl; ENSOART00000002943.1; ENSOARP00000002886.1; ENSOARG00000002717.1.
DR Proteomes; UP000002356; Chromosome 14.
DR Bgee; ENSOARG00000002717; Expressed in ileocolic lymph node and 51 other cell types or tissues.
DR ExpressionAtlas; W5NXI9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.30.70.680; TRADD, N-terminal domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR035712; TRADD.
DR InterPro; IPR009095; TRADD_N.
DR InterPro; IPR036729; TRADD_N_sf.
DR PANTHER; PTHR14913; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR14913:SF0; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR Pfam; PF09034; TRADD_N; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF55044; TRADD, N-terminal domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 217..308
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 169..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 34678 MW; 4A9B5660FC813015 CRC64;
GKMAAGSNGL EEWVGSAYLF VESSLDKVVL SDAYAHQQQK VGMYRALRTA LAESGGSPDV
LQMLKIHRSD PQLIVQLRFS GRLACSRFLR AYREGALRAT LQGCLARALA LNSVPLQLEL
RAGAEQLDAL LTDEERCLNC ICAQKPDRLR DEELTELEDA LRNLKCGSAA GQGSDVQGTP
APSQSLAPSP PEEKPPPPPP GQTFLFQGQP IVNRPLNLQD QQKFARSVGL KWRKVGRSLQ
RSCRALRDPA LDSLAYEYER EGLYEQAFQL LRRFVQAAEG RRATLQRLVE ALEENELTSL
AEDLLGLANP EGSLV
//
