ID W5NXN0_SHEEP Unreviewed; 310 AA.
AC W5NXN0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Matrix metalloproteinase-23 {ECO:0008006|Google:ProtNLM};
GN Name=MMP23B {ECO:0000313|Ensembl:ENSOARP00000002927.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000002927.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000002927.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000002927.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000002927.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01005}.
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DR EMBL; AMGL01021942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01021943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NXN0; -.
DR SMR; W5NXN0; -.
DR STRING; 9940.ENSOARP00000002927; -.
DR PaxDb; 9940-ENSOARP00000002927; -.
DR Ensembl; ENSOART00000002986.1; ENSOARP00000002927.1; ENSOARG00000002757.1.
DR eggNOG; KOG1565; Eukaryota.
DR HOGENOM; CLU_015489_2_1_1; -.
DR OMA; WGVQARC; -.
DR Proteomes; UP000002356; Chromosome 12.
DR Bgee; ENSOARG00000002757; Expressed in aortic valve and 49 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 1.10.10.1940; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003582; ShKT_dom.
DR Pfam; PF01549; ShK; 1.
DR SMART; SM00254; ShKT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51670; SHKT; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU01005};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 175..209
FT /note="ShKT"
FT /evidence="ECO:0000259|PROSITE:PS51670"
FT DOMAIN 215..300
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DISULFID 175..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01005"
SQ SEQUENCE 310 AA; 33989 MW; CD75F5DD120F63C0 CRC64;
MGRGACVPSA ASGAGDQARR LGALLGALCL FPALVLLAWP GTPATRAGAR AAQLNAAPQT
SCVLASGNLG PPQPPAPRRR RYTLTPARLR WEHFNLTYKC GPGPGRWGVQ ARCLLAATPD
RDSYPRGVAV PLPPPHPEAL SQARAPPGFY PVNHTDCLVS PPPPRSDRAS AFAGCLDRLF
VCASWARRGF CDARRRLMKR LCPSSCDFCY EFPFPTVAAT PPPPRTKTKL VPEGRNVTFR
CGQKILHKKG KVYWYKDQEP LEFSYPGYLA LGEAHLSIIA NAINEGTYTC VVRRRQRVLS
TYSWRIRVRS
//
