ID W5NY99_SHEEP Unreviewed; 520 AA.
AC W5NY99;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Fascin domain-containing protein {ECO:0000259|Pfam:PF06268};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003147.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003147.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003147.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003147.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415}.
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DR EMBL; AMGL01069621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01069622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01069623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01069624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NY99; -.
DR SMR; W5NY99; -.
DR STRING; 9940.ENSOARP00000003147; -.
DR PaxDb; 9940-ENSOARP00000003147; -.
DR Ensembl; ENSOART00000003207.1; ENSOARP00000003147.1; ENSOARG00000002959.1.
DR eggNOG; ENOG502QPRX; Eukaryota.
DR HOGENOM; CLU_030960_2_0_1; -.
DR OMA; NIFSMTR; -.
DR Proteomes; UP000002356; Chromosome 24.
DR Bgee; ENSOARG00000002959; Expressed in prescapular lymph node and 53 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00257; Fascin; 3.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF23; FASCIN; 1.
DR Pfam; PF06268; Fascin; 3.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 3.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 46..159
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 301..404
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 419..520
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 520 AA; 57795 MW; D4B5D18B03BEB8F4 CRC64;
LGLGRPPRGP LLWASPQAAA PRGWGFGIGG KGAVAQIQFG LINCSNKYLT AETFGFKVNA
SASSLKKKQI WTLEQPPDEA GSAAVCLRSH LGRYLAADKD GNVTCEHEAP GADCRFLIVA
HDDGRWSLQS EAHRRYFGGT EDRLSCFAQT VSPAEKWSVH IAMHPQVNIY SLARKRYAHL
GARPADEISV DRDVPWGVDS LITLAFQDQR YSLHCAQFVL QAANERNVST RQDSAPGGFS
SFWRPCPFFG PEGSLFLPPR GTSGCLAPSR HTRWGRTRVW VSQQGCRQVT LAPGNSSYNF
RTWTRMDLSA NQDEETDQET FQLEIDRDTK KCAFRTHSGK YWTLTTTGGV QSTASTKDAR
CYFDIEWRDR RIILRASNGK FVTAKKNGQL AASVETTGDS ELFLMKLINR PIIVFRGEHG
FIGCRKVTGT LDANRSNYDV FQLEFRDGAY NIKDSTGKYW MVGNDSSVTS SSDSPVDFFL
EFCDYNKVAI KVGGHYLKGD HAGVLKACAD TIDPTTLWEY
//
