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Database: UniProt
Entry: W5NZ72_SHEEP
LinkDB: W5NZ72_SHEEP
Original site: W5NZ72_SHEEP 
ID   W5NZ72_SHEEP            Unreviewed;       758 AA.
AC   W5NZ72;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   31-JUL-2019, entry version 32.
DE   RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN   Name=IKBKB {ECO:0000313|Ensembl:ENSOARP00000003470};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003470, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000003470, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003470};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000003470}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AMGL01073438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01073439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01073440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01073441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01073442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01073443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01073444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01073445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01073446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9940.ENSOARP00000003470; -.
DR   Ensembl; ENSOART00000003534; ENSOARP00000003470; ENSOARG00000003246.
DR   GeneTree; ENSGT00950000182937; -.
DR   OMA; AEAHTLC; -.
DR   Proteomes; UP000002356; Chromosome 26.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0008384; F:IkappaB kinase activity; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:1903347; P:negative regulation of bicellular tight junction assembly; IEA:Ensembl.
DR   GO; GO:0035509; P:negative regulation of myosin-light-chain-phosphatase activity; IEA:Ensembl.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:1903140; P:regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0042325; P:regulation of phosphorylation; IEA:Ensembl.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR   InterPro; IPR041185; IKBKB_SDD.
DR   InterPro; IPR022007; IKKbetaNEMObind.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   Pfam; PF18397; IKBKB_SDD; 1.
DR   Pfam; PF12179; IKKbetaNEMObind; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM01239; IKKbetaNEMObind; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN       15    302       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION      669    707       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      739    758       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      562    582       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    672    694       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   758 AA;  86569 MW;  97855453C1936123 CRC64;
     MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQETGEQ IAIKQCRQEL SPRNRERWCL
     EIQIMRRLNH PNVVAARDVP EGMQSLAPND LPLLAMEYCQ GGDLRKKYLN QFENCCGLRE
     GAILTLLSDI ASALRYLHEN RIIHRDLKPE NIVLQQGEQR LIHKIIDLGY AKELDQGSLC
     TSFVGTLQYL GAQGLEQAQQ DLVIDCMQMM TRKFFYTISD TSKGSPSWKT VHRHSKVRQK
     SEMDIVVSED LNGAVKFSSS LPHPNNLNSV LAQRLEKWLQ LMLMWHPRQR GTDPVYGPNG
     CFKALDDILN LKLLHVLNMV TGTLHTYPVT EDESLQSLKA RIRQDTGILE EDQELLQEAG
     LALIPDKPAA QCLSDGKLNE GRTLDMDLVF LFDNSRVTYE SQVSPQPQPE SVSCILQEPK
     RNLPFFQLRK VWGQVWHSIQ ALKEDCSRLQ QGQRAAMMNL LRNNSCLSKM KNSMASMSQQ
     LKAKLDFFKT SIQIDLEKYR EQTEFGITSD KLLLAWREME QAVELCGREN EVKHLVERMM
     ALQTDIVDLQ RSPMGRKQGG TLDDLEEQAR ELYRRLREKP RDQRTDGDSQ EMVRLLLQAI
     QGFEKKVRVI YTQLSKTVVC KQKALELLPK VEEVVSLMSE DEKTVVRLQE KRQKELWNLL
     KIACSKVRGP VSGSPDSMNA SRLSHPSQLM SQPCAAPDSL PEAAEKSDDL VAEAHTLCTQ
     LENALQDTMK EQDQSLRSLD WSWLQSEEEE QQGLERAS
//
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