ID W5NZS6_SHEEP Unreviewed; 776 AA.
AC W5NZS6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=CDH3 {ECO:0000313|Ensembl:ENSOARP00000003674.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003674.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003674.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003674.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003674.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AMGL01028322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NZS6; -.
DR SMR; W5NZS6; -.
DR STRING; 9940.ENSOARP00000003674; -.
DR PaxDb; 9940-ENSOARP00000003674; -.
DR Ensembl; ENSOART00000003741.1; ENSOARP00000003674.1; ENSOARG00000003438.1.
DR eggNOG; KOG3594; Eukaryota.
DR HOGENOM; CLU_005284_2_0_1; -.
DR OMA; EAQNQHT; -.
DR Proteomes; UP000002356; Chromosome 14.
DR Bgee; ENSOARG00000003438; Expressed in epididymis and 52 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF444; CADHERIN-3; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 4.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 602..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..160
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 161..273
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 274..385
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 386..493
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 776 AA; 85718 MW; BE8CE1013A295261 CRC64;
VFTDCPGQEA ALLTDDDFIV LNDETVQTKL LIYERKALKI SPPTPVLRRR KREWVVPPIS
VPENGKGPFP QRLNQLKSNK DRGTKIFYSI TGPGADSPPE GIFAIEKETG WLLLNKPLDR
EKIAKYELFG HAVSENGASV EDPMNISIIV TDQNDHKPKF TQDVFRGSVL EGVLPGTSVM
QVTATDEDDA VNTYNGVVAY SIHSQEPKDP HDLMFTVHRS TGTISVISSG LDRERVPEYT
LTIHATDMDG DGSSTTAMAI VEILDANDNA PVFDPQKYEA RVPENTVSHE VQRLTVTDLD
APNSPAWRAT YRIVGGDNGD RFTITTDPES NQGILTTKKD LDFEAKTQHT LYVEVINEVP
FVVKLPTSTA TIVVHVEDVN EPPVFVPPSK VIKIQEGISI GEPVCNYTAQ DPDKGSQKIS
YRILRDPAGW LAMDPDSGQV TAAGILDRED EQFVRNNIYE VMVLATDDGS PPITGTGTLL
LTLMDINDHG PVPEPRQITI CNQSPVPQVL NITDKDLSPH TAPFQAQLTH DSDVYWTAEV
SEKGDTVALS LKKFLKQDNY DVHLSLSDHG NKEQLTVIKA TVCNCHGHVE KDTCAEPWKG
GFLLPILGAA LALLLLLLVL LFLVRKKRKI KEPLLLPEDD TRDNVFYYGE EGGGEEDQDY
DITQLHRGLE ARPEVVLRND VAPSFIPTPM YRPRPANPDE IGNFIIENLK AANTDPTAPP
YDSLLVFDYE GSGSDAASLS SLTSSTSDQD QDYNYLNEWG SRFKKLADMY GGGQDD
//
