ID W5P005_SHEEP Unreviewed; 941 AA.
AC W5P005;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|ARBA:ARBA00029784, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|ARBA:ARBA00032199, ECO:0000256|RuleBase:RU366037};
GN Name=XPOT {ECO:0000313|Ensembl:ENSOARP00000003753.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000003753.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000003753.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000003753.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000003753.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|RuleBase:RU366037}.
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DR EMBL; AMGL01081193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P005; -.
DR Ensembl; ENSOART00000003820.1; ENSOARP00000003753.1; ENSOARG00000003504.1.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000003504; Expressed in gastric lymph node and 55 other cell types or tissues.
DR ExpressionAtlas; W5P005; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 2.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 21..89
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00913"
SQ SEQUENCE 941 AA; 107680 MW; 313A35A03C51F9F2 CRC64;
MDEQALLGLN PNADSDFRQR ALAYFEQLKI SPDAWQVCAE ALAQRTYSDD HIKFFCFQVL
EHQVKYKYSE LTTVQQQLIR ETLVSWLQAQ MLNPQPEKTF IRNKAAQVFA LLFVTEYLTK
WPKFFFDILS VVDLNPRGVD LYLRILMAID SELVDRDVVH TSEEARRNTL IKDTMREQCI
PNLVESWYQI LQNYQYTNSE VTCQCLEVVG AYVSWIDLSL IANDRFINML LGHMSIEVLR
EEACDCLFEI VNKGMDPVDK MKLVESLCQV LQSAGFFSID REEDVDFLAR FSKLVNGMGQ
SLIVSWTKLI KNGDIKNAQE ALQAIETKVA LMLQLLIHED DDISSNIIGF CYDYLHILKQ
LTVLSDQQKA NVEAIMLAVM KKLTYDEEYN FENEGEDEAM FVEYRKQLKL LLDRLAQVSP
ELLLASVRRV FSSTLQNWQT TRFMEVEVAI RLLYMLAEAL PVSHGAHFSG DVSKASALQD
MMRTLVTSGV SSYQHTSVTL EFFETVVRYE KFFTVEPQHI PCVLMAFLDH RGLRHSSAKV
RSRTAYLFSR FVKSLNKQMN PFIEDILNRI QDLLELSPPE NGYQSLLSSD DQLFIYETAG
VLIVNSEYPA ERKQALMRNL LTPLMEKFKI LLEKLMLAQD EERQASLADC LNHAVGFASR
TSKAFSNKQT VKQCGCSEVY LDCLQTFLPA LSCPLQKDIL RSGVRTFLHR MIICLEEEVL
PFIPSASEHM LKDCEAKDLQ EFIPLINQIT AKFKIQVSPF LQQMFMPLLH AMLRRSYFAF
LQTVTGSGMS EVIANQGAEN VERVLVTVIQ GAVEYPDPIA QKTCFIILSK LVELWGGKDG
PVGFADFVYK HIVPACFLAP LKQTFDLADA QTVLALSECA VTLKTIHLKR GPECVQYLQQ
EYLPSLQVAP EIIQEFCQAL QQPDAKVFKN YLKVFFQRAK P
//
