ID W5P1D2_SHEEP Unreviewed; 495 AA.
AC W5P1D2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RasGEF domain family member 1A {ECO:0008006|Google:ProtNLM};
GN Name=RASGEF1A {ECO:0000313|Ensembl:ENSOARP00000004231.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004231.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004231.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004231.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004231.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01070941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01070942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P1D2; -.
DR SMR; W5P1D2; -.
DR STRING; 9940.ENSOARP00000004231; -.
DR PaxDb; 9940-ENSOARP00000004231; -.
DR Ensembl; ENSOART00000004305.1; ENSOARP00000004231.1; ENSOARG00000003959.1.
DR eggNOG; KOG3541; Eukaryota.
DR HOGENOM; CLU_022907_2_0_1; -.
DR OMA; IAKECCE; -.
DR Proteomes; UP000002356; Chromosome 25.
DR Bgee; ENSOARG00000003959; Expressed in cerebellum and 51 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF172; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1A; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 48..184
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 228..475
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 495 AA; 55749 MW; 4DC8229A65BF1D08 CRC64;
PIPSSQETMP QTSVVFSSIL GPSCSGQGQP GMGERGGGAG GSGDLIFQDG RLISGSLELR
GRPVLRGSGE GPPSVGPISE RTYIFTFLLS SRVFIPPHDL LARVGQLCVE QRQQLEAGSE
KAKLKSFSAK IVQLLKEWTE AFPFDFQDEK AMAELKAITH RVTQCDEENG TVKKAIAQMT
QSLLLSLAAR SQLQELREKL RSPAMDKGPV LKAKPPAAQK DILGVCCDPL VLAQQLTHIE
LERVSSIHPE DLMQIVSHTD SRDKHRCRGD MTKTYSLEAY DNWFNCLSML VATEVCRVVK
KKHRTRMLEF FIDVARECFN IGNFNSMMAI ISGMNLSPVA RLKKTWSKVK TAKFDVLEHH
MDPSSNFCNY RTALQGATQR SQTANSSREK IVIPVFNLFV KDIYFLHKIH TNHLPNGHIN
FKKFWEISRQ IHEFMTWTQV ECPFEKDKKI QSYLLTAPIY SEEALFIASF ESEGPENHME
KDSWKTLRTT LLNRA
//
