ID W5P1V4_SHEEP Unreviewed; 548 AA.
AC W5P1V4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Connector enhancer of kinase suppressor of ras 3 {ECO:0008006|Google:ProtNLM};
GN Name=CNKSR3 {ECO:0000313|Ensembl:ENSOARP00000004403.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004403.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004403.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004403.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004403.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR EMBL; AMGL01108492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01108493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01108494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01108495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01108496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01108497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01108498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01108499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01108500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014952980.1; XM_015097494.1.
DR AlphaFoldDB; W5P1V4; -.
DR Ensembl; ENSOART00000004480.1; ENSOARP00000004403.1; ENSOARG00000004106.1.
DR HOGENOM; CLU_037920_0_0_1; -.
DR Proteomes; UP000002356; Chromosome 8.
DR Bgee; ENSOARG00000004106; Expressed in thyroid gland and 52 other cell types or tissues.
DR ExpressionAtlas; W5P1V4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR010599; CNK2/3_dom.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF17; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 3; 1.
DR Pfam; PF06663; CNK2_3_dom; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 1..66
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 74..168
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 205..287
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 303..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 60888 MW; 5ECDF9BCC8F64A88 CRC64;
MTIMDSFAFL VGLDDCLQQY VHKFEREKIN GEQLLQISHQ DLEELGVTRI GHQELVLEAV
DLLCALNYGL ETDNMKNLVL KLRASSHNLQ NYISSRRKSP AYDGNTSHKP PNEFLTSVVE
LIGAAKALLA WLDRAPFTGI TDFSVTKNKI IQLCLDLTTT VQKDCLVAEM EDKVLAVVKV
LNGICDKTIR STTDPVMSQC ACLEEVHLPN IKPGEGLGMY IKSTYDGLHV ITGTTENSPA
DRSQKIHAGD EVIQVNQQTV VGWQLKNLVR KLRENPTGVV LLLKKRPTSS FNFTPAPLKN
LRWRPPLVQT SPPTTTTQSP DSTMDASLKK EKPAILDLYI PPPPSVPYSP REENGGSVYG
FSKCKQPQPG PKGSESPNSF LDQESRRRRF TIADSDQLPG YSVETNILPA KMREKTPSYG
KPRPLSMPAD ASWMGIVDPF ARPRGHGRKS EDALCRYFSN ERIPPILEES SSPTYRFSRP
ATERQLVRGA DYIRGSRCYI SSDLHSSATI PFPEEGTKKK AGSSAAKSSS PEPSLLVSWL
TRLKLLTH
//
