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Database: UniProt
Entry: W5P239_SHEEP
LinkDB: W5P239_SHEEP
Original site: W5P239_SHEEP 
ID   W5P239_SHEEP            Unreviewed;       719 AA.
AC   W5P239;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 30.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 3 {ECO:0000313|Ensembl:ENSOARP00000004488};
GN   Name=HCN3 {ECO:0000313|Ensembl:ENSOARP00000004488};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004488, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000004488, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004488};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000004488}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AMGL01004843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01004844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01004845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000004568; ENSOARP00000004488; ENSOARG00000004200.
DR   GeneTree; ENSGT00900000140801; -.
DR   OMA; VMEQHLV; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   Proteomes; UP000002356; Chromosome 1.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|SAAS:SAAS00084808};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM     95    119       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      429    535       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   719 AA;  80550 MW;  5047C2015C41605C CRC64;
     HSVTGRVALG EGWQESVARK KPPAAPASTT TASGPVPGSR PGPEPKRRQL GTLLQPTVNK
     FSLRVFGSHK AVEIEQERVK SAGAWIIHPY SDFRFYWDLI MLLLMVGNLI VLPVGITFFK
     EENSPPWIVF NVLSDTFFLM DLVLNFRTGI VVEEGAEILL APRAIRTRYL RTWFLVDLIS
     SIPVDYIFLV VELEPRLDAE VYKTARALRI VRFTKILSLL RLLRLSRLIR YIHQWEEIFH
     MTYDLASAVV RIFNLIGMML LLCHWDGCLQ FLVPMLQDFP PDCWVSISHM VNHSWGRQYS
     HALFKAMSHM LCIGYGQQAP VGMPDVWLTM LSMIVGATCY AMFIGHATAL IQSLDSSRRQ
     YQEKYKQVEQ YMSFHKLPAD TRQRIHEYYE HRYQGKMFDE ESILGELSEP LREEIINFTC
     RGLVAHMPLF AHADPSFVTA VLTKLRFEVF QPGDLVVREG SVGRKMYFIQ HGLLSVLAHG
     ARDTRLTDGS YFGEICLLTR GRRTASVRAD TYCRLYSLSV DHFNAVLEEF PMMRRAFETV
     AMDRLRRIGK KNSILQRKRS EPSPGSSGGV MEQHLVQHDR DMARGVRGLA PSTGARLRGK
     PELGGATAAA VTSSVAIALT HQRGPLPLSP DSPVTLLARS ARRSAGRLPS LPRGRPLSAS
     QPSLPQRAAG DGSPGRKSSG SERLPPSGLL TKPPGTAQPP RLPVPEPATP RGPQLSANM
//
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