ID W5P2F9_SHEEP Unreviewed; 1140 AA.
AC W5P2F9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN Name=ATP9B {ECO:0000313|Ensembl:ENSOARP00000004608.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004608.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004608.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004608.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004608.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00034036,
CC ECO:0000256|RuleBase:RU362033};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IV subfamily. {ECO:0000256|ARBA:ARBA00008109,
CC ECO:0000256|RuleBase:RU362033}.
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DR EMBL; AMGL01065161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P2F9; -.
DR SMR; W5P2F9; -.
DR STRING; 9940.ENSOARP00000004608; -.
DR PaxDb; 9940-ENSOARP00000004608; -.
DR Ensembl; ENSOART00000004689.1; ENSOARP00000004608.1; ENSOARG00000004295.1.
DR eggNOG; KOG0210; Eukaryota.
DR HOGENOM; CLU_000846_3_1_1; -.
DR OMA; IAITTWH; -.
DR Proteomes; UP000002356; Chromosome 23.
DR Bgee; ENSOARG00000004295; Expressed in epididymis and 51 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR CDD; cd07541; P-type_ATPase_APLT_Neo1-like; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006539; P-type_ATPase_IV.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR24092:SF50; PHOSPHOLIPID-TRANSPORTING ATPASE IIB-RELATED; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362033};
KW Magnesium {ECO:0000256|RuleBase:RU362033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362033};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362033}.
FT TRANSMEM 181..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 384..403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 967..987
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1017..1037
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1043..1064
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1071..1091
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1097..1123
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT DOMAIN 128..184
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT DOMAIN 951..1132
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
FT REGION 514..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 127240 MW; 7E39D7813916A3DE CRC64;
LAPSPPHDAP RAAAAVAAAN RKRAAYFSAA GPGPGPDRPS RYQLEDESAH LDEMPLMMSE
EGFENDESDY HTLPRARITR RKRGLEWFVC GGWKFLCTSC CDWLINICQR KRELKARTVW
LGCPEKCEEK HPRNSIKNQK YNIFTFIPGV LYEQFKFFLN LYFLIVSCSQ FVPALKIGYL
YTYWAPLGFV LAVTIMREAV DEFRRFQRDK EVNSQLYSKL TVRGKVQVKS SDIQVGDLII
VEKNQRIPSD MVFLRTSEKA GSCFIRTDQL DGETDWKLKV AVSCTQRLPA LGDLFSINAY
VYAQKPQLDI HSFEGTFTRE DSDPPVHESL SIENTLWAST VVASGTVIGV VIYTGKETRS
VMNTSNPKNK VGLLDLELNQ LTKALFLALV ALSVVMVTLQ GFAGPWYRSL FRFLLLFSYI
IPISLRVNLD MGKAAYGWMI MKDEHIPGTV VRTSTIPEEL GRLVYLLTDK TGTLTQNEMV
FKRLHLGTVS YGTDTMDEIQ NHLVNAYAQT QCQAGGSSTI STPPRKAASS APKVRRSVSS
RVHEAVKAVA LCHNVTPVYE ARGAAGETEV AEADQDFSDD NRTYQASSPD EVALVQWTES
VGLTLVSRDL TSMQLRTPSG QILTFCILQT FPFTSESKRM GVIVRDESTA EITFYMKGAD
VAMASIVQYN DWLEEECGNM AREGLRTLVV AKRALTEEQY QDFESRYNQA KLSLHDRTLK
ESLEREMELL CLTGVEDQLQ ADVRPTLEML RNAGIKIWML TGDKLETATC IAKSSHLVSR
TQDTHVFRPV TSRGEAHLEL NAFRRKHDCA LVIPGDALEV CLKYYEHEFV ELACQCPAVV
CCRCSPTQKA HIVKLLQQHT GRRTCAIGDG GNDVSMIQAA DCGIGIEGKG GGEAGPTALR
EQLPEGQVGT VTTCHDPVPW PVCPLSSCEN TQRGGACTGS RPLCFLGPQS AVFSSVFYFA
SVPLYQGFLM VGYATAYTMF PVFSLVLDQD VKPEMAMLYP ELYKDLTKGR SLSFKTFLIW
VLISIYQGGI LMFGALVLFE SEFVHVVAIS FTALVLTELL MVALTVRTWH WLMVVAQLLS
LGCYVASLAF LNEYFDVAFI TTVTFVWKVS AITVVSCLPL YVLKYLKRKL SPPSYSKLSS
//
