ID W5P2V3_SHEEP Unreviewed; 493 AA.
AC W5P2V3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Xaa-Pro dipeptidase {ECO:0000256|ARBA:ARBA00044141};
DE EC=3.4.13.9 {ECO:0000256|ARBA:ARBA00044051};
DE AltName: Full=Imidodipeptidase {ECO:0000256|ARBA:ARBA00044351};
DE AltName: Full=Peptidase D {ECO:0000256|ARBA:ARBA00044252};
DE AltName: Full=Proline dipeptidase {ECO:0000256|ARBA:ARBA00044284};
GN Name=PEPD {ECO:0000313|Ensembl:ENSOARP00000004753.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004753.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004753.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004753.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004753.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline;
CC Xref=Rhea:RHEA:76407, ChEBI:CHEBI:15377, ChEBI:CHEBI:59869,
CC ChEBI:CHEBI:60039, ChEBI:CHEBI:195196; EC=3.4.13.9;
CC Evidence={ECO:0000256|ARBA:ARBA00043793};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the peptidase M24B family. Eukaryotic-type
CC prolidase subfamily. {ECO:0000256|ARBA:ARBA00043990}.
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DR EMBL; AMGL01028588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01028589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01028590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01028591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01028592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004015193.1; XM_004015144.3.
DR AlphaFoldDB; W5P2V3; -.
DR MEROPS; M24.007; -.
DR Ensembl; ENSOART00000004834.1; ENSOARP00000004753.1; ENSOARG00000004434.1.
DR GeneID; 101110862; -.
DR KEGG; oas:101110862; -.
DR CTD; 5184; -.
DR HOGENOM; CLU_017266_1_2_1; -.
DR OrthoDB; 1377484at2759; -.
DR Proteomes; UP000002356; Chromosome 14.
DR Bgee; ENSOARG00000004434; Expressed in adult mammalian kidney and 53 other cell types or tissues.
DR ExpressionAtlas; W5P2V3; baseline.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01087; Prolidase; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR48392; -; 1.
DR PANTHER; PTHR48392:SF2; PEPTIDASE D; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 18..155
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
SQ SEQUENCE 493 AA; 54859 MW; 59CC2A52D878DC76 CRC64;
MAAATGPSFW LGNETLKVPL ALFALNRQRL CERLRKNPAV QAGSVVVLQG GEETQRYCTD
TGVLFRQESF FHWAFGVTEP GCYGVIDVDT GTSTLFVPRL PPSHATWMGK IHSKEHFKEK
YAVNDVQYTD EIASVLTSRS PSVLLTLRGV NTDSGSICRE ASFEGISKFN VNNTILHPEI
VECRVFKTDM ELEVLRYTNK ISSEAHREVM KAVKVGMKEY EMESLFEHYC YSRGGMRHSS
YTCICGSGEN SAVLHYGHAG APNDKTIQDG DMCVFDMGGE YYCFASDITC SFPANGKFTP
DQKAIYEAVL RSCRAVMSAM KPGVWWPDMH RLADRIHLEE LARIGLLTGS VDAMVQVHLG
AVFMPHGLGH FLGLDVHDVG GYPEGVDRID EPGLRRLRTA RHLEPRMVLT VEPGIYFIDH
LLDEALADPA RACFFNREVL QRFRGFGGVR IEEDVVVTDT GMELLTCVPR TVEEVEACMA
GQDKAFAPFS GPK
//
