ID W5P326_SHEEP Unreviewed; 1019 AA.
AC W5P326;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=C2H2-type domain-containing protein {ECO:0000259|PROSITE:PS50157};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004826.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004826.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004826.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AMGL01065276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01065282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000004826; -.
DR PaxDb; 9940-ENSOARP00000004826; -.
DR Ensembl; ENSOART00000004908.1; ENSOARP00000004826.1; ENSOARG00000004510.1.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_009481_0_0_1; -.
DR OMA; YQGWGVG; -.
DR Proteomes; UP000002356; Chromosome 23.
DR Bgee; ENSOARG00000004510; Expressed in epididymis and 51 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45925; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR45925:SF3; ZINC FINGER PROTEIN 516; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 34..61
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 62..84
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 193..220
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 221..243
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 280..307
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 954..977
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..880
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 108290 MW; A953E2374BC113CC CRC64;
MERSREAEAE LRGGRSPPRA SRSPEADGDR ALSYSCCICG KTFPFQSSLS QHMRKHTGEK
PYKCPYCDHR AAQKGNLKIH IRGHRAGTLT QGREPEAAET RGSEXRRRSA RKEAEGAAAG
QCAFCKSRFE RKKDLARHVQ QAHKPFTCRL CSYATLREEA LLSHVEKDHI AAQGPRGDAF
AENGKPELPP GEFPCEVCGQ AFSQTWFLKA HMKKHRGSFD HGCHICGRRF KEPWFLKNHM
KAHGPKAGSK NRPRSELEPV ATINDVVQEE VIVAGLSLYE VCTKCGNLFT NLDSLNAHNA
IHRRVEAGQP RAAVGEGSAT GPADSQQLFL QCLNLRPAAG TPARGQTGRR VAELDPVNSY
QAWQLATRGK VAEPAEYLKY AAWDEALAGD VAFDKERREF ILVSQEKRKR EPEPGAXGPG
DRAPRARCGS LSEGDSASQP SSPGSGCAAA DSPGSGLADE AADESGEEAP AHPAAAGSPH
IQVARVQETV ARVLMQAHSA SDISKQRPGD GAPPRRALLF SPSAGAHTLS SASLLAPDSS
SIMIDVRCPV IKLRREFSGL KSIVKYPSVG ETEACRFWNL STRGCLPEQP CPCHSRSPGQ
PPAGSRPSAL AAGERATSPL PLMPSASPSA LAGGVLSPVP GPAALWGHTR GLWHSVSPFF
FFPQMVTRWG ELCIFKRIFL PVMKTLPSPP PLLLGSGSSP APLEEFYDRA KRGGAPRSPA
ASPAGPALAA LLQTRPGGTG DGCASQSVLR GCEGVAEQTL CSLGSEPHSP MRSMPPWPLL
KARPRAERGE RAPSAGQAPA RRRKPRPSPA AGAPASPPAA TGQGHSHPLG PSLAEGAAGG
RHPAPHPGKQ VGGGGPGPQG PGDLPPCPAP ALPPREPPSK AASRGPAAPQ GPPAPHPVKQ
EPASEGPEKR LDLLSIFKTY IPKDLASLYQ SWGASSPVLE RRGTLRTQAH QGDFICVECG
KSFHQPSHLR AHMRAHTVLF ESNGLRGADA HATSADAPKQ GRDHSNADAV QTVPLRKGT
//
