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Database: UniProt
Entry: W5P362_SHEEP
LinkDB: W5P362_SHEEP
Original site: W5P362_SHEEP 
ID   W5P362_SHEEP            Unreviewed;        39 AA.
AC   W5P362;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Stress-associated endoplasmic reticulum protein {ECO:0000256|RuleBase:RU364120};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004862.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000004862.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004862.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000004862.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Interacts with target proteins during their translocation
CC       into the lumen of the endoplasmic reticulum. Protects unfolded target
CC       proteins against degradation during ER stress. May facilitate
CC       glycosylation of target proteins after termination of ER stress. May
CC       modulate the use of N-glycosylation sites on target proteins.
CC       {ECO:0000256|ARBA:ARBA00037157}.
CC   -!- FUNCTION: May interact with target proteins during translocation into
CC       the lumen of the endoplasmic reticulum. May protect unfolded target
CC       proteins against degradation and facilitate correct glycosylation.
CC       {ECO:0000256|RuleBase:RU364120}.
CC   -!- SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex.
CC       Interacts with CANX. {ECO:0000256|ARBA:ARBA00038831}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU364120}; Single-
CC       pass type IV membrane protein {ECO:0000256|RuleBase:RU364120}.
CC       Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU364120}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU364120}; Cytoplasmic side
CC       {ECO:0000256|RuleBase:RU364120}.
CC   -!- SIMILARITY: Belongs to the RAMP4 family.
CC       {ECO:0000256|ARBA:ARBA00005500, ECO:0000256|RuleBase:RU364120}.
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DR   EMBL; AMGL01010878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5P362; -.
DR   STRING; 9940.ENSOARP00000004862; -.
DR   PaxDb; 9940-ENSOARP00000004862; -.
DR   Ensembl; ENSOART00000004945.1; ENSOARP00000004862.1; ENSOARG00000004546.1.
DR   eggNOG; KOG3491; Eukaryota.
DR   HOGENOM; CLU_3322323_0_0_1; -.
DR   Proteomes; UP000002356; Chromosome 1.
DR   Bgee; ENSOARG00000004546; Expressed in adrenal cortex and 53 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010580; ER_stress-assoc.
DR   PANTHER; PTHR15601; STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4; 1.
DR   PANTHER; PTHR15601:SF14; STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 1; 1.
DR   Pfam; PF06624; RAMP4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU364120};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364120};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU364120};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Translocation {ECO:0000256|RuleBase:RU364120};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU364120};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU364120};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU364120}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364120"
SQ   SEQUENCE   39 AA;  4322 MW;  51EB068FFC2B93D7 CRC64;
     QRNAPEEKAS VGPWLLALFI FVVCGSAIFQ IIQSIRMGM
//
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