ID W5P362_SHEEP Unreviewed; 39 AA.
AC W5P362;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Stress-associated endoplasmic reticulum protein {ECO:0000256|RuleBase:RU364120};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004862.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004862.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004862.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004862.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Interacts with target proteins during their translocation
CC into the lumen of the endoplasmic reticulum. Protects unfolded target
CC proteins against degradation during ER stress. May facilitate
CC glycosylation of target proteins after termination of ER stress. May
CC modulate the use of N-glycosylation sites on target proteins.
CC {ECO:0000256|ARBA:ARBA00037157}.
CC -!- FUNCTION: May interact with target proteins during translocation into
CC the lumen of the endoplasmic reticulum. May protect unfolded target
CC proteins against degradation and facilitate correct glycosylation.
CC {ECO:0000256|RuleBase:RU364120}.
CC -!- SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex.
CC Interacts with CANX. {ECO:0000256|ARBA:ARBA00038831}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU364120}; Single-
CC pass type IV membrane protein {ECO:0000256|RuleBase:RU364120}.
CC Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU364120}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU364120}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU364120}.
CC -!- SIMILARITY: Belongs to the RAMP4 family.
CC {ECO:0000256|ARBA:ARBA00005500, ECO:0000256|RuleBase:RU364120}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01010878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P362; -.
DR STRING; 9940.ENSOARP00000004862; -.
DR PaxDb; 9940-ENSOARP00000004862; -.
DR Ensembl; ENSOART00000004945.1; ENSOARP00000004862.1; ENSOARG00000004546.1.
DR eggNOG; KOG3491; Eukaryota.
DR HOGENOM; CLU_3322323_0_0_1; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000004546; Expressed in adrenal cortex and 53 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010580; ER_stress-assoc.
DR PANTHER; PTHR15601; STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4; 1.
DR PANTHER; PTHR15601:SF14; STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 1; 1.
DR Pfam; PF06624; RAMP4; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU364120};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364120};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU364120};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Translocation {ECO:0000256|RuleBase:RU364120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364120};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364120};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU364120}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364120"
SQ SEQUENCE 39 AA; 4322 MW; 51EB068FFC2B93D7 CRC64;
QRNAPEEKAS VGPWLLALFI FVVCGSAIFQ IIQSIRMGM
//