ID W5P3E4_SHEEP Unreviewed; 570 AA.
AC W5P3E4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Zinc finger protein 181 {ECO:0008006|Google:ProtNLM};
GN Name=ZNF181 {ECO:0000313|Ensembl:ENSOARP00000004944.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004944.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000004944.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004944.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000004944.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AMGL01028672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014955456.1; XM_015099970.1.
DR AlphaFoldDB; W5P3E4; -.
DR SMR; W5P3E4; -.
DR STRING; 9940.ENSOARP00000004944; -.
DR PaxDb; 9940-ENSOARP00000004944; -.
DR Ensembl; ENSOART00000005028.1; ENSOARP00000004944.1; ENSOARG00000004622.1.
DR GeneID; 101114378; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_44_5_1; -.
DR OMA; KEDICDE; -.
DR OrthoDB; 3120634at2759; -.
DR Proteomes; UP000002356; Chromosome 14.
DR Bgee; ENSOARG00000004622; Expressed in thymus and 52 other cell types or tissues.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23226:SF416; ZINC FINGER PROTEIN 46; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 236..263
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 264..291
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 292..319
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 320..347
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 348..375
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 376..403
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 404..431
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 432..459
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 460..487
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 488..515
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 516..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 570 AA; 65840 MW; D6BC6DDE54AC2AEA CRC64;
MFQVTFSDVA IDFSHEEWRW LSSTQRDLYK DVMVQNYENL VSLGLSIPKP YVIALLEDGK
EPWMVEEKLS KDMFSDCKSR WENKELSVKE DIYDEDLPQM VIKEKTTQQN NKFSNFNKDL
YYIKKLEGKY ENQVEHFRPV TLTFRESPIG ESVYKCNVFK SIFHLKSIFS EPQRISAEGK
SHKCDILKKS LPTNSVIKNE NISDGKKLLN SNESVAAFSQ SKSLTLHQTL NREKIYTCSE
CGKAFGKQSI LNRHWRIHTG EKPYECHECG KTFSHGSSLT RHQISHSGEK PYKCIECGKA
FSHVSSLTNH QSTHTGEKPY ECMNCGKAFS RVSHLIEHLR IHTQEKLYEC RICGKAFIHR
SSLIHHQKIH TGEKPYECRE CGKAFCCSSH LTRHQRIHAI EKQFECNKCL KVFSSLSFLI
QHQSIHTEEK PFECQKCGKS FNQPESLNMH LRNHTRLKPY ECSICGKAFS HRSSLFQHHR
IHTGEKPYEC IKCGKTFSCS SNLTVHQRIH TGEKPYKCNE CGKAFSKGSN LTAHQRVHNG
EKPSSTISVG KSLGHMSHCV YERSHNRETA
//
