ID W5P412_SHEEP Unreviewed; 486 AA.
AC W5P412;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Lysophospholipid acyltransferase 5 {ECO:0000256|ARBA:ARBA00039721};
DE EC=2.3.1.23 {ECO:0000256|ARBA:ARBA00026120};
DE EC=2.3.1.n6 {ECO:0000256|ARBA:ARBA00038923};
GN Name=LPCAT3 {ECO:0000313|Ensembl:ENSOARP00000005164.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005164.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005164.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005164.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005164.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; phospholipid metabolism.
CC {ECO:0000256|ARBA:ARBA00005074}.
CC -!- PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010323}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01083587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P412; -.
DR Ensembl; ENSOART00000005251.1; ENSOARP00000005164.1; ENSOARG00000004814.1.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000004814; Expressed in duodenum and 56 other cell types or tissues.
DR ExpressionAtlas; W5P412; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR004299; MBOAT_fam.
DR PANTHER; PTHR13906:SF14; LYSOPHOSPHOLIPID ACYLTRANSFERASE 5; 1.
DR PANTHER; PTHR13906; PORCUPINE; 1.
DR Pfam; PF03062; MBOAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 486 AA; 55839 MW; 56282D551A690398 CRC64;
MASAAEGDME AELTRGLQWG FQDLSLNKLA TSLGASEQAL RLIISIFLGY PLALFYRRYL
FYKDSYLIHL FHTFTGLSIA YYNFGTQLYH SLLCIVLQFL ILRLMGRTIT AVLTTFCVRA
GGYLLAGYYN TATGTYDIKW TMPHCVLTLK LIGLAIDYYD GGKDQKSLTS EQQIYAIRGV
PSLLEVAGFS YFYGAFLVGP QFSMNHYMKL VRGELTDVPG KIPNSTIPAL RRLALGLVYL
VGYTLLSPHI TEDYLLSDDY ENGSFWFRCM YMLLWGKFVL YKYVTCWLVT EGVCILTGLG
FNGFDEYGTA KWDACANMKV WLFETNPRFT GTIASFNINT NAWVSRYFFK RLKFLGNKVL
SQGLSLLFLA LWHGLHSGYL VCFQMEFLIV IVERQAASLI RDSPVLSRLA SITVLQPVYY
LVQQTIHWLF MGYSMTAFCL FTWDKWMKVY KSIYFLGHVF FLSLLFILPY VRKVMVPRKE
KLKKME
//
