ID W5P4C7_SHEEP Unreviewed; 418 AA.
AC W5P4C7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
GN Name=SEPTIN7 {ECO:0000313|Ensembl:ENSOARP00000005279.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005279.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005279.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005279.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Filament-forming cytoskeletal GTPase.
CC {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SUBUNIT: Septins polymerize into heterooligomeric protein complexes
CC that form filaments. {ECO:0000256|PIRNR:PIRNR006698}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cleavage furrow
CC {ECO:0000256|ARBA:ARBA00004626}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR EMBL; AMGL01087618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01087619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01087620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01087621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01087622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01087623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P4C7; -.
DR SMR; W5P4C7; -.
DR STRING; 9940.ENSOARP00000005279; -.
DR PaxDb; 9940-ENSOARP00000005279; -.
DR Ensembl; ENSOART00000005366.1; ENSOARP00000005279.1; ENSOARG00000004927.1.
DR eggNOG; KOG2655; Eukaryota.
DR HOGENOM; CLU_017718_8_1_1; -.
DR OMA; RSNPMGS; -.
DR Proteomes; UP000002356; Chromosome 4.
DR Bgee; ENSOARG00000004927; Expressed in spleen and 52 other cell types or tissues.
DR GO; GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0031105; C:septin complex; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR InterPro; IPR008115; Septin7.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF126; SEPTIN; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR PRINTS; PR01742; SEPTIN7.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212, ECO:0000256|PIRNR:PIRNR006698};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR006698};
KW Differentiation {ECO:0000256|ARBA:ARBA00022871};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 27..297
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 359..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 48744 MW; E01EDD260F93BD29 CRC64;
MGQQKNLEGY VGFANLPNQV YRKSVKRGFE FTLMVVGESG LGKSTLINSL FLTDLYSPEY
PGPSHRIKKT VQVEQSKVLI KEGGVQLLLT IVDTPGFGDA VDNSNCWQPV IDYIDSKFED
YLNAESRVNR RQMPDNRVQC CLYFIAPSGH GLKPLDIEFM KRLHEKVNII PLIAKADTLT
PEECQQFKKQ IMKEIQEHKI KIYEFPETDD EEENKLVKKI KDRLPLAVVG SNTIIEVNGK
RVRGRQYPWG VAEVVENGEH CDFTILRNML IRTHMQDLKD VTNNVHYENY RSRKLAAVTY
NGVDNNKNKG QLTKSPLAQM EEERREHVAK MKKMEMEMEQ VFEMKVKEKV QKLKDSEAEL
QRRHEQMKKN LEAQHKELEE KRRQFEDEKA NWEAQQRILE QQNSSRTLEK NKKKGKIF
//
