ID W5P4I2_SHEEP Unreviewed; 380 AA.
AC W5P4I2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005335.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005335.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005335.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005335.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; AMGL01062499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01062500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01062501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P4I2; -.
DR Ensembl; ENSOART00000005422.1; ENSOARP00000005335.1; ENSOARG00000004979.1.
DR Proteomes; UP000002356; Chromosome 21.
DR Bgee; ENSOARG00000004979; Expressed in gastric lymph node and 54 other cell types or tissues.
DR ExpressionAtlas; W5P4I2; baseline.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF42; CATHEPSIN D; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 291..375
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 229..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 297..334
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 380 AA; 40473 MW; 61FC7D74DF32E692 CRC64;
PDLRLDRIPL QKFTSIRRTM SEAMGPVEHL IAKGPISKYA TGEPAVRQGP IPELLKNYMD
FTWARLPGGH PPPWSPCAVS PVLLEGLWQP QPRPCTLPSC SVSDQPVCPL LAEGETSSEV
GHCGTHSVLG QVTRQCAEVV RGGHGQGVGW AACCSWSLVT TPHMPRLGLT LGPSGGIPAQ
SLWPGLCMDA GLCPLLSQWA ASPPPGSPWF SFQACEVPTP GPLALASSSA CWPNPGRPRG
ADWDPSRSRQ DLLSGRSLAC GPRGVRLEHS PTSPPLAPPP PAPPGRPPLR GTYMIPCEKV
SSLPQVTLKL GGKDYTLSPE DYTLKVSQAG TTVCLSGFMG MDIPPPGGPL WILGDVFIGR
YYTVFDRDQN RVGLAEAARL
//
