ID   W5P5G7_SHEEP            Unreviewed;       366 AA.
AC   W5P5G7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=CMP/dCMP-type deaminase domain-containing protein {ECO:0000259|PROSITE:PS51747};
GN   Name=APOBEC4 {ECO:0000313|Ensembl:ENSOARP00000005670.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005670.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000005670.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005670.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000005670.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; AMGL01022495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5P5G7; -.
DR   STRING; 9940.ENSOARP00000005670; -.
DR   PaxDb; 9940-ENSOARP00000005670; -.
DR   Ensembl; ENSOART00000005758.1; ENSOARP00000005670.1; ENSOARG00000005287.1.
DR   eggNOG; ENOG502QQXT; Eukaryota.
DR   HOGENOM; CLU_832944_0_0_1; -.
DR   OMA; HNAYEIN; -.
DR   Proteomes; UP000002356; Chromosome 12.
DR   Bgee; ENSOARG00000005287; Expressed in fallopian tube and 8 other cell types or tissues.
DR   GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   InterPro; IPR038953; APOBEC4.
DR   InterPro; IPR013158; APOBEC_N.
DR   InterPro; IPR002125; CMP_dCMP_dom.
DR   PANTHER; PTHR35672; C-U-EDITING ENZYME APOBEC-4-RELATED; 1.
DR   PANTHER; PTHR35672:SF1; C-U-EDITING ENZYME APOBEC-4-RELATED; 1.
DR   Pfam; PF08210; APOBEC_N; 1.
DR   PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN          61..177
FT                   /note="CMP/dCMP-type deaminase"
FT                   /evidence="ECO:0000259|PROSITE:PS51747"
SQ   SEQUENCE   366 AA;  41326 MW;  E4138C638928AF4F CRC64;
     MEPLYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVPYTEFYQ IFGFPYGPTY
     PPTKHLTFYE LKTSSGSLVQ KGHASSCTGN DTHPESMLFE MNGYFDSAVH SNDGMRHIIL
     YSSNSPCNEA NHCCISKMYT FLAKYPDITL SIYFSQLYHT EAEFPASPWN REALRSLASL
     SPRVTLSPIS GGMWYSLLSN FVSGVQGATV FQPILTGRAL ADRHNAHEIN AITGVKPYFT
     DVLQAKENPN VKVQAALEGY PLNNVFPRQS FQVTSRQLQS NLTLDPRVPV IFVLVPYRDL
     PPIHVGPSPQ KPRNIIRHLN MPQISFQETG DLRKSPIGMP VERVEITGQF ASSKEENEKK
     KKKGKN
//