ID W5P5W1_SHEEP Unreviewed; 1039 AA.
AC W5P5W1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000005814.1};
GN Name=ITGA3 {ECO:0000313|Ensembl:ENSOARP00000005814.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005814.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005814.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005814.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005814.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AMGL01018399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P5W1; -.
DR SMR; W5P5W1; -.
DR STRING; 9940.ENSOARP00000005814; -.
DR PaxDb; 9940-ENSOARP00000005814; -.
DR Ensembl; ENSOART00000005904.1; ENSOARP00000005814.1; ENSOARG00000005412.1.
DR eggNOG; KOG3637; Eukaryota.
DR HOGENOM; CLU_004111_1_0_1; -.
DR OMA; RYNHTGA; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000005412; Expressed in rectum and 53 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 33..1039
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001426614"
FT TRANSMEM 980..1002
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 38..103
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 235..291
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 292..353
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 354..410
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 414..476
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 461..613
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 614..752
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 762..967
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1039 AA; 115178 MW; ABE74EC502E3187F CRC64;
SGQAPARAAG VLRPLLGMLA LMVAASNRAA SAFNLDTRFL VVKEAGNPGS LFGYSVALHR
QTERQQRYLL LAGAPRDLAV PDGYTNRTGA VYLCPLTAHK NDCERVDIKE KSNPNHIIED
MWLGVTVASQ GPAGRVLVCA HRYTQVLWSG SEDQRRMVGK CYVRGNDLEL DARDDWQTYH
NEMCNSNTDY LETGMCQLGT SGGFTQNTVY FGAPGAYNWK GNSYMIQRKD WDLSEYSYKD
PEDQGNLYIG YTMQVGSAIL HPTNITIVTG APRHQHVGAV FLLSQEAGGD LRRRQVLEGT
QVGAYFGSAI ALADLNNDGW QDLLVGAPYY FERKEEVGGA IYIFMNQAGT SFPDRPSLLL
HGPSRSAFGF SVASIGDINQ DGFQDIAVGA PFEGSGKVYI YHGSSRGLLR QPQQVIHGEQ
LGLPGLATFG YSLSGQMDVD ENFYPDLLVG SLSDRIVLLR ARPVINILHK TLVARPSILD
PAFCTATSCV QVELCFAYNQ SAGNPNYRRN ITLAYTLEAD RDRRPPRLHF ARSQSAVFHG
FFSMPEMRCQ TLELLLMDNV RDKLRPITIS MNYSLPLRLP DRPQLGLGSL DAYPVLNQAQ
ALENHTEVQF QKECGQDNRC DSNLQMRAAF VSELGQRLSR LQYGRDLRKL LLSINVTNTP
SRKRAGEDAH EALLTLEVPP TLLLSSVRPP GACQANETIV CELGNPFKRN QRMELLIAFE
VIGVTLHTRE LQAQLQLSTS SHQDDLRPMT LPLLVDYTLQ ASLSMVNHRL QSFFGGTVMG
ESGMKTVEDV GSPLKYEFQV GPMGEGLAAL GTLVLGLEWP YEVSNGKWLL YPTEITVRGN
GSWHCRPPGD LINPLNLTLS VPGDKPPAPQ QGPPPVTLAA AKKAKSEIQL SCGSDHTHCV
WLECPIPDAP VITNVTIQAR VWNSTFIEDY RDFDRVRVAS WATLFLRTSV PTINMENKTV
RFSVDIDSDL VEELPAEIEL WLVLVAVSAG LLLLGLIILL LWKCGFFKRA RTRALYEAKR
QKAEMKSQPS ETERLTEDY
//
