ID W5P5W2_SHEEP Unreviewed; 687 AA.
AC W5P5W2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Zinc finger protein 420 {ECO:0008006|Google:ProtNLM};
GN Name=LOC101102414 {ECO:0000313|Ensembl:ENSOARP00000005815.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005815.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005815.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005815.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005815.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMGL01028761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01028762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004015248.1; XM_004015199.3.
DR RefSeq; XP_012045739.1; XM_012190349.2.
DR RefSeq; XP_012045741.1; XM_012190351.2.
DR AlphaFoldDB; W5P5W2; -.
DR SMR; W5P5W2; -.
DR STRING; 9940.ENSOARP00000005815; -.
DR PaxDb; 9940-ENSOARP00000005815; -.
DR Ensembl; ENSOART00000005905.1; ENSOARP00000005815.1; ENSOARG00000005420.1.
DR GeneID; 101102414; -.
DR KEGG; oas:101102414; -.
DR CTD; 147923; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_44_5_1; -.
DR OMA; QWEMSER; -.
DR OrthoDB; 3776076at2759; -.
DR Proteomes; UP000002356; Chromosome 14.
DR Bgee; ENSOARG00000005420; Expressed in thymus and 53 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 19.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24393:SF167; ZINC FINGER PROTEIN 345-RELATED; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 19.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 6..95
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 138..165
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 166..193
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 194..221
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 222..249
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 250..277
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 278..305
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 306..333
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 334..361
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 362..389
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 390..417
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 418..445
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 446..473
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 474..501
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 502..529
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 530..557
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 558..585
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 586..613
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 614..641
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 642..669
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 687 AA; 79844 MW; 434B71DCCD0C3598 CRC64;
MAQRSVMFRD VAIDFSQEEW DCLDSAQRDL YRDVMLENYS NLVSLDLPSR RANKLLSPKK
DIYETELSQW EMSARLENCD LENSSSRDYL EVKGTLEKQQ ENQEYFSQGM IIYDKMSIFN
QHAYLSQHPR CHSTEKPYKC KECGKAFRRA SHLTQHQSIH TGEKPYECKQ CGKAFSRDSQ
LSLHQRLHTG EKPYACKECG KAFTQSSQLI LHHRIHTGEK PYKCEECGKA FIRSSQLTRH
QKVHTGEKPY ECKECGKAFT QNSQLTLHQR LHTGEKLYEC KECRKVFTQL SQLILHKRIH
TGEKPYECKE CGKAFICGSQ LSQHQKIHNG EKPYECQECG KAFIRGSLLM QHQRIHTGEK
PYKCEECGKA FIRGSQLTQH QRIHTNEKPY ECKECGKTFS HGSQLTQHQR IHTGEKPYQC
KECGKAFNRG SLLTRHQRIH TGEKPYECKE CGKTFSRGSE LTQHERIHTG EKPYECKECG
KSFIRGSQLT QHQRIHTGEK PYECKECRMA FTQSSHLSQH QRLHTGEKPY VCNECGKAFA
RGLLLIQHQR IHTGEKPYQC KECGKAFIRG SQLTQHQRIH TGEKPYGCKE CGKAFSHGSQ
LTLHQRIHTG EKPYECKECR KAFTQSSHLS RHQRVHTGEK PYQCQECGKA FTRGSQLTQH
QRIHISEKSF EYKECGIDFS HDSQVYI
//
