ID W5P632_SHEEP Unreviewed; 350 AA.
AC W5P632;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Proline-rich transmembrane protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=PRRT2 {ECO:0000313|Ensembl:ENSOARP00000005886.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005886.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005886.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005886.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family.
CC {ECO:0000256|ARBA:ARBA00006843}.
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DR EMBL; AMGL01069040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P632; -.
DR STRING; 9940.ENSOARP00000005886; -.
DR PaxDb; 9940-ENSOARP00000005886; -.
DR Ensembl; ENSOART00000005976.1; ENSOARP00000005886.1; ENSOARG00000005482.1.
DR eggNOG; ENOG502S2U1; Eukaryota.
DR HOGENOM; CLU_070349_0_0_1; -.
DR OMA; DPQPDCQ; -.
DR Proteomes; UP000002356; Chromosome 24.
DR Bgee; ENSOARG00000005482; Expressed in cerebellum and 49 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR PANTHER; PTHR14948; NG5; 1.
DR PANTHER; PTHR14948:SF20; PROLINE-RICH TRANSMEMBRANE PROTEIN 2; 1.
DR Pfam; PF04505; CD225; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 278..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..151
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..221
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 35927 MW; 0367A37E6691EDD4 CRC64;
MAASSSEISE IKAVEEGPQT QGEGPGHSEG QTGSPQVPAG VSDEPETLQP GPDVMGAPVD
SEPKVGLAPE TTETPTGAPE AAQARDLSSS PGGEAKANSS TEETCQELAS KPEVSKEATA
DPESNLESAA PLEPASEPAP QPEPQLDPQP EPQPASQSTS TPALQPEPPT QEEPTSEILS
ENMGEKQENG AVVPLQAGDG DGEEGPAPQP HSPPSTKTPP ANGAPPRVLQ QLVEEDRLGK
AHSGHSGSPR GSLSRHPSSQ LAGSGVEGGE GTQKPRDYII LAILSCFCPM WPVNIVAFAY
AVMSRNSLQQ GDVDGAQRLG RVAKLLSIVA LVGGILIIIA SCVINLGVYK
//
