ID W5P675_SHEEP Unreviewed; 708 AA.
AC W5P675;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=SEFIR domain-containing protein {ECO:0000259|PROSITE:PS51534};
GN Name=IL17RC {ECO:0000313|Ensembl:ENSOARP00000005929.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005929.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000005929.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005929.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000005929.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01044467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01044468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P675; -.
DR SMR; W5P675; -.
DR STRING; 9940.ENSOARP00000005929; -.
DR PaxDb; 9940-ENSOARP00000005929; -.
DR Ensembl; ENSOART00000006019.1; ENSOARP00000005929.1; ENSOARG00000005521.1.
DR eggNOG; ENOG502RYE0; Eukaryota.
DR HOGENOM; CLU_026893_1_0_1; -.
DR OMA; GHPNICV; -.
DR Proteomes; UP000002356; Chromosome 19.
DR Bgee; ENSOARG00000005521; Expressed in abomasum and 51 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.11530; -; 1.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR027841; IL-17_rcpt_C/E_N.
DR InterPro; IPR013568; SEFIR_dom.
DR PANTHER; PTHR15583; INTERLEUKIN-17 RECEPTOR; 1.
DR PANTHER; PTHR15583:SF12; INTERLEUKIN-17 RECEPTOR C; 1.
DR Pfam; PF15037; IL17_R_N; 1.
DR Pfam; PF08357; SEFIR; 1.
DR PROSITE; PS51534; SEFIR; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..708
FT /note="SEFIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004870334"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 510..662
FT /note="SEFIR"
FT /evidence="ECO:0000259|PROSITE:PS51534"
SQ SEQUENCE 708 AA; 77923 MW; 038F1CD8EC497C19 CRC64;
MPVPWFLLSL ALGRNPVVLS LERVVGPQDT ARCSPGLSCH LWDGDVLCLP GSLVSAPGPV
LVPTRLQTEL VLRCHEETDC DLCVRVAVHL AVHGYWEDPE DEEKFRRAAD PELEEPRNAS
LQAHIVLSFQ AYPTAHCVLL EVQVPAALVQ PGQSVGSIVF DCFEAALGAE VQIWSYTQPR
YQKELNLTQQ LPDCRGLEVQ DNIQSCWALP WLNVSADGED VRLVLDVSEE QRFGLSLYWN
QDQGPIKPWW HSNLTGPQTI TLNHTDLVPC LCIQVWPLEP DSVRTSICPF REDPRAHRNL
WRAARLQLLP SLGWLRCSLP AEATLCWQAL DGGPCLPLVP PLPRENVTVN KVLEFPLRKG
HPNVCVQVST WEKLQMQECL WADSLGPLKD DMLLVETRGP QDNGSLCALE PSGCTPLLSR
ASTRAARLGE QLLQDVQSGQ CLQLWDSDLG ALWACPMDKY IHQRWALVWL ACLLLAAVLF
LLLLLKMNPV KGWLRLLKEN IRAGGACPRG AGPALLYSAD DASFERLVGA LASALCQLPL
RVAVDLWSRR DLSAQGALAW FHAQRRQTLQ EGGVVVLLFS PGAVALCREW LQDATSAPRA
HGPHDAFAAS LSCVLPDFLQ GRAPGRYVGA YFDKLLPADA VPALFRSVPV FSLPSQLPDF
LGILQGPTAP RSRRLAERAE QVSRALQPAL DSCFRPPGAL GTGCGMGP
//
