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Database: UniProt
Entry: W5P6R6_SHEEP
LinkDB: W5P6R6_SHEEP
Original site: W5P6R6_SHEEP 
ID   W5P6R6_SHEEP            Unreviewed;       514 AA.
AC   W5P6R6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   08-MAY-2019, entry version 34.
DE   RecName: Full=Ubiquitinyl hydrolase 1 {ECO:0000256|SAAS:SAAS01044305};
DE            EC=3.4.19.12 {ECO:0000256|SAAS:SAAS01044305};
GN   Name=USP27X {ECO:0000313|Ensembl:ENSOARP00000006120};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006120, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000006120, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006120};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000006120}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide,
CC         peptide and isopeptide bonds formed by the C-terminal Gly of
CC         ubiquitin (a 76-residue protein attached to proteins as an
CC         intracellular targeting signal).; EC=3.4.19.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01117307};
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|SAAS:SAAS01045498}.
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DR   EMBL; AMGL01115488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9940.ENSOARP00000006120; -.
DR   Ensembl; ENSOART00000006214; ENSOARP00000006120; ENSOARG00000005706.
DR   GeneTree; ENSGT00940000162674; -.
DR   OMA; KYPTWET; -.
DR   Proteomes; UP000002356; Chromosome X.
DR   GO; GO:1990380; F:Lys48-specific deubiquitinase activity; IEA:Ensembl.
DR   GO; GO:0061578; F:Lys63-specific deubiquitinase activity; IEA:Ensembl.
DR   GO; GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01044238};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01044152};
KW   Protease {ECO:0000256|SAAS:SAAS01044292};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Thiol protease {ECO:0000256|SAAS:SAAS01044269};
KW   Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01044331};
KW   Zinc {ECO:0000256|SAAS:SAAS01044373};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS01044352}.
FT   DOMAIN       25     85       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   DOMAIN      155    498       USP. {ECO:0000259|PROSITE:PS50235}.
FT   ZN_FING      25     85       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
SQ   SEQUENCE   514 AA;  58381 MW;  B69DCD40A7B1E95E CRC64;
     ELRVIYQCFV WCGTPETRKS KAKSCICHVC GTHLNRLHSC LSCVFFGCFT EKHIHEHAET
     KQHNLAVDLY YGGIYCFMCK DYVYDRDIEQ IAKEEQGEAL KLQASTSTEV SHQQYSMPGL
     GEKYPTWETT KPELELLGHN PRRRRIASSF TIGLRGLINL GNTCFMNCIV QALTHTPILR
     DFFLSDRHRC EMPSPELCLV CEMSSLFREL YSGNPSPHVP YKLLHLVWIH ARHLAGYRQQ
     DAHEFLIAAL DVLHRHCKGD DAGKAASNPN HCNCIIDQIF TGGLQSDVTC QACHGVSTTI
     DPCWDISLDL PGSCTSFWPM SPGRESSVNG ESHIPGITTL TDCLRRFTRP EHLGSSAKIK
     CGSCQSYQES TKQLTMNKLP VVACFHFKRF EHSAKQRRKI TTYISFPLEL DMTPFMASSK
     ESRMNGQLQL PTNSGNDENK YSLFAVVNHQ GTLESGHYTS FIRHHKDQWF KCDDAVITKA
     SIKDVLDSEG YLLFYHKQVL EHESEKVKEV NTQA
//
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