ID W5P6Y3_SHEEP Unreviewed; 490 AA.
AC W5P6Y3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Zinc finger protein 397 {ECO:0008006|Google:ProtNLM};
GN Name=ZNF397 {ECO:0000313|Ensembl:ENSOARP00000006187.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006187.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006187.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006187.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006187.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187}.
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DR EMBL; AMGL01066173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P6Y3; -.
DR SMR; W5P6Y3; -.
DR STRING; 9940.ENSOARP00000006187; -.
DR PaxDb; 9940-ENSOARP00000006187; -.
DR Ensembl; ENSOART00000006281.1; ENSOARP00000006187.1; ENSOARG00000005768.1.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_49_3_1; -.
DR OMA; DCENSES; -.
DR Proteomes; UP000002356; Chromosome 23.
DR Bgee; ENSOARG00000005768; Expressed in embryo and 52 other cell types or tissues.
DR ExpressionAtlas; W5P6Y3; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1.
DR PANTHER; PTHR23232:SF90; KRAB DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00187};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 50..132
FT /note="SCAN box"
FT /evidence="ECO:0000259|PROSITE:PS50804"
FT DOMAIN 284..311
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 312..339
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 340..367
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 368..395
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 396..423
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 424..451
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 452..479
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 480..490
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 195..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 56113 MW; 96730F3028B1115A CRC64;
MALESRAVST PVPQNSQEQE LILVKVEESC SWGQKLKQNG STRSCQELFR QQFRKFCYQE
TPGPREALGR LQELCYQWLR PELHTKEQIL ELLVLEQFLS ILPEELQIWV QQHSPKNGEE
AVTLLEDLER EFDDPGQQVP ASPQGPAMPW KDLTCLGAAQ EFTHIQRQPL KKQLKPWEPC
LSPKSGCENN ELATKDISGE KSQRLSQEPS FGGFSEHKSS LEWQQGSAPG ETLRRSPSQG
ASFSPVIFTH KSLGNRDHPE PQRNLILSTN SVTYQRFPKE ERPYRCDICG HSFKQHSSLT
QHQRIHTGEK PYKCNQCGKA FSLRSYLIIH QRIHSGEKAY ECSECGKAFN QSSALIRHRK
IHTGEKACKC NECGKAFSQS SYLIIHQRIH TGEKPYECNE CGKTFSQSSK LIRHQRIHTG
ERPYECNECG KAFRQSSELI THQRIHSGEK PYECNECGKA FSLSSNLIRH QRIHSGEEPY
QCNECGKTFK
//
