ID W5P6Z9_SHEEP Unreviewed; 1820 AA.
AC W5P6Z9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Kinesin-like protein KIF1B {ECO:0008006|Google:ProtNLM};
GN Name=KIF1B {ECO:0000313|Ensembl:ENSOARP00000006203.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006203.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006203.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006203.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006203.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; AMGL01021601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01021602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01021603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01021604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01021605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01021606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5P6Z9; -.
DR STRING; 9940.ENSOARP00000006203; -.
DR PaxDb; 9940-ENSOARP00000006203; -.
DR Ensembl; ENSOART00000006297.1; ENSOARP00000006203.1; ENSOARG00000005770.1.
DR eggNOG; KOG0245; Eukaryota.
DR OMA; IKITICH; -.
DR Proteomes; UP000002356; Chromosome 12.
DR Bgee; ENSOARG00000005770; Expressed in cerebellum and 55 other cell types or tissues.
DR ExpressionAtlas; W5P6Z9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22727; FHA_KIF1B; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..354
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 558..614
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1705..1803
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1555..1574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 677..733
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1555..1572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1820 AA; 204680 MW; 7DCD29AB264F5EBA CRC64;
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT
SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP
QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGHLRVRE HPLLGPYVED
LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DTETNLSTEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRSRYA DRAKQIKCNA
VINEDPNAKL VRELKEEVTR LKDLLRAQGL GDIIDIDPLI DDYSGSGGKY LKDFQNNKHR
YLLASENQRP GNFSTASMGS LTSSPSSCSL NSQVGLTSVT SIQERIMSTP GGEEAIERLK
ESEKIIAELN ETWEEKLRKT EAIRMEREAL LAEMGVAIRE DGGTLGVFSP KKTPHLVNLN
EDPLMSECLL YYIKDGITRV GQADAERRQD IVLSGAHIKE EHCIFRSERN NSGDVIVTLE
PCERSETYVN GKRVTQPVQL RSGNRIIMGK NHVFRFNHPE QARAEREKTP SAETPSEPVD
WTFAQRELLE KQGIDMKQEM EKRLQEMEIL YKKEKEEADL LLEQQRLDYE SKLQALQKQV
ETRSLAAETT EEEEEEEEVP WTQHEFELAQ WAFRKWKSHQ FTSLRDLLWG NAVYLKEANA
ISVELKKKVQ FQFVLLTDTL YSPLPPELLP TETEKTQEDR PFPRTVVAVE VQDLKNGATH
YWSLEKLKQR LDLMREMYDR AGEMASSTQD ESETTMTGSD PFYDRFHWFK LVGSSPIFHG
CVNERLADRT PSPTFSTADS DITELADEQQ EEMEDFDEEA FVDDTGSDAG TEEGSDLFSD
GHDPFYDRSP WFILVGRAFV YLSNLLYPVP LIHRVAIVSE KGEVRGFLRV AVQAIAGLAD
EEAPDYGSGI RQSGTAKISF DNEYFNQSDI SSVALTRSGL SLEELRIVEG QGQSSEVITP
PEEVNRMNDL DLKSSTLLDG KMMMEGFSEE IGNHLKLGSA FTFRVTVLQA SGILPEYADI
FCQFNFLHRH DEAFSTEPLK NNGRGSPLGF YHVQNIAVEV TESFVDYIKT KPIVFEVFGH
YQQHPLHLQG QELNSPPQPS RRFFPPPMPL SKPVPATKLN TMSKTSLGQS MSKYDLLVWF
EISELEPTGE YIPAVVDHTA GLPCQGTFLL HQGIQRRITV TIIHEKGSEL HWKDVRELVV
GRIRNKAEVD EAAVDAILSL NIISAKYLKS SHNSSRTFYR FEAVWDSSLH NSLLLNRVTP
YGEKIYMTLS AYLELDHCIQ PAVITKDVCM VFYSRDAKIS PPRSLRSLFG SGYSKSPDSN
RVTGIYELSL CKMADTGSPG MQRRRRKILD TSVAYVRGEE NLAGWRPRGD SLILEHQWEL
EKLELLHEVE KTHHFLLLRD RLGDSIPKSL SDSLSPSLSS GTLSTSTSIS SQISTTTFES
AITPSESSGY DSADIESLVD REKELATKCL QLLTHTFNRE FSQVHGSISD CKLADLSPVG
RDPSVSSLSS STLTPSSTCP SLVDARSNSL DQKTPEANSR ASSPCPEFEQ FQIVPPVETP
YLARAGKNEF LNLVPDIEEI RPGSVVSKKG YLHFKEPLSS NWAKHFVVVR RPYVFIYNSD
KDPVERGIIN LSTAQVEYSE DQQAMVKTPN TFAVCTKHRG VLLQALNDKD VNDWLYAFNP
LLAGTIRSKL SRRCPSQAKY
//
