ID W5P7G0_SHEEP Unreviewed; 506 AA.
AC W5P7G0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=C2H2-type domain-containing protein {ECO:0000259|PROSITE:PS50157};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006364.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006364.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006364.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006364.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. ZBTB18 subfamily. {ECO:0000256|ARBA:ARBA00038422}.
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DR EMBL; AMGL01021227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P7G0; -.
DR SMR; W5P7G0; -.
DR STRING; 9940.ENSOARP00000006364; -.
DR PaxDb; 9940-ENSOARP00000006364; -.
DR Ensembl; ENSOART00000006461.1; ENSOARP00000006364.1; ENSOARG00000005939.1.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_034521_0_0_1; -.
DR OMA; GASDYDM; -.
DR Proteomes; UP000002356; Chromosome 12.
DR Bgee; ENSOARG00000005939; Expressed in cerebellum and 52 other cell types or tissues.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24394:SF18; ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR24394; ZINC FINGER PROTEIN; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 427..454
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 455..482
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 483..506
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 153..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 56567 MW; 9E7878E058811BD7 CRC64;
LLWDTDQGED VRNFTEKLSL LVCFFSTDVT DLEPARLRGK DLIRFMCPKG YEDSMEFPDH
SRHLLQCLSE QRHQGFLCDC TVLVGDDQLD KRDIVHLNSD IVTAPAFALL LEFMYEGKLQ
FKDLPIEDVL AAASYLHMYD IVKVCKKKLK EKATTEADST KKEEDASSCS DKVESLSDGS
SHMAGDLPSD EDEGEDEKLN ILPSKRDLAA EPGNMWMRLP SDSAGIPQAG GEAEPHATAA
GKTVASPCSS TESLSQRSVT SVRDSADVDC VLDLSVKSSL SGVENLNSSY FSSQDVLRSN
LVQVKVEKEA SCDESDVGTN DYDMEHSTVK ESVSTNNRVQ YEPAHLAPLR EDSVLRELER
EDKASDDEMM TPESERVQVE GGMESSLLPY VSNILSPAGQ IFMCPLCNKV FPSPHILQIH
LADVNVPTCS LCGKTFSCMY TLKRHERTHS GEKPYTCTQC GKSFQYSHNL SRHAVVHTRE
KPHACKWCER RFTQSGDLYR HIRKFH
//
