ID W5P7U5_SHEEP Unreviewed; 346 AA.
AC W5P7U5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
GN Name=NODAL {ECO:0000313|Ensembl:ENSOARP00000006499.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006499.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006499.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006499.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006499.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AMGL01071393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004021483.3; XM_004021434.3.
DR AlphaFoldDB; W5P7U5; -.
DR SMR; W5P7U5; -.
DR STRING; 9940.ENSOARP00000006499; -.
DR PaxDb; 9940-ENSOARP00000006499; -.
DR Ensembl; ENSOART00000006597.1; ENSOARP00000006499.1; ENSOARG00000006065.1.
DR GeneID; 101110384; -.
DR KEGG; oas:101110384; -.
DR CTD; 4838; -.
DR eggNOG; KOG3900; Eukaryota.
DR HOGENOM; CLU_020515_1_0_1; -.
DR OMA; MHLYRNF; -.
DR OrthoDB; 5393576at2759; -.
DR Proteomes; UP000002356; Chromosome 25.
DR Bgee; ENSOARG00000006065; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..346
FT /note="TGF-beta family profile domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868708"
FT DOMAIN 233..346
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 346 AA; 39921 MW; B5F1DB9C85ECAA12 CRC64;
MDAHRLWLFL LHAWWALLQA GAAMVAPVPL RPWGQPSSPS PLAYMLSLYR EPLTRADIIR
SLQAQDMQVD GQNWTFAFDF SFLSQEEDLE WAELRLQLSS PVALPPNIPL SVEIFHQRKL
DKNPPDCLER FRMDLFTVSL SQVTFSLGSM VLEVTRPLSK WLKHPGGLRE QMSSLAGECW
RRTPTPPVTD VLLLLYSNLS PEQRRLGGST LLWEAESSWR AQEGQLSRER GTRHRRYHVQ
DRSQLCRKVK FQVDFNLIGW GSWIIYPKQY NAYRCEGECP NPVGEEFHPT NHAYIQSLLK
RYQPHRVPAT CCAPVKTKPL SMLYVDNGRV LLDHHKDMIV EECGCL
//
