ID W5P8J4_SHEEP Unreviewed; 527 AA.
AC W5P8J4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=T-cell surface glycoprotein CD4 {ECO:0000256|ARBA:ARBA00016522};
DE AltName: Full=T-cell surface antigen T4/Leu-3 {ECO:0000256|ARBA:ARBA00029974};
GN Name=CD4 {ECO:0000313|Ensembl:ENSOARP00000006749.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006749.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006749.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006749.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006749.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AMGL01083603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P8J4; -.
DR SMR; W5P8J4; -.
DR Ensembl; ENSOART00000006853.1; ENSOARP00000006749.1; ENSOARG00000006301.1.
DR OMA; KTCQCSH; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000006301; Expressed in major salivary gland and 44 other cell types or tissues.
DR ExpressionAtlas; W5P8J4; baseline.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 1.20.5.900; transmembrane domain of human cd4; 1.
DR InterPro; IPR000973; CD4.
DR InterPro; IPR015274; CD4-extracel.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008424; Ig_C2-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR021963; Tcell_CD4_Cterm.
DR PANTHER; PTHR11422; T-CELL SURFACE GLYCOPROTEIN CD4; 1.
DR PANTHER; PTHR11422:SF0; T-CELL SURFACE GLYCOPROTEIN CD4; 1.
DR Pfam; PF05790; C2-set; 2.
DR Pfam; PF09191; CD4-extracel; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF12104; Tcell_CD4_C; 1.
DR PRINTS; PR00692; CD4TCANTIGEN.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..527
FT /note="T-cell surface glycoprotein CD4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004868738"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 136..194
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 472..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 57932 MW; C5AB58B1AB99E222 CRC64;
MGPGTSLRHL FLVLQLVMLP AGTQGKAVVL GKAGGQAELP CQASQKKNIV FSWKDSSQSK
ILGSHNSFLH KGNTELSHRV ESKKNLWDQG SFPLIIKNLQ VTDSGTYTCE VDSKKLEVEL
KVFGLTASSD TRVLLGQSLT LTLESPSGSN PSVQWKGPGN NRKEELKSLS LAQVGLQDSG
TWTCTISQSQ QTLEIKIPIV VLAFQKAPET VYVKEGEQAE FSFPLTFEDE NLSGELTWQQ
ANKDSSSQSW VTFTLRNREV KVNKTHKDVK LHMGERLPLR LTLQRTLPQY AGSGTLTLDL
TKGKLHQKVN LVVMTVTKSP NSLTCEVLGP SPPRLTLNLK LGNQSMKSSN QPKVVTELEP
KAGMWQCLLS DQGKVLLESK IEVLPSEFIQ AWPKLLPMVL GGIAGLALLT GSCIFCVKCW
HRRVSELSLT SSRPHGALKT LRPVRAKVSH VYDLLLLWLP LPTAPSLTAG WAPSQIPGGG
REGKAQSQFW DRWPPQPQPW PLPSPPSPPP PPPKRLLSEK KTCQCPQ
//
