GenomeNet

Database: UniProt
Entry: W5P923_SHEEP
LinkDB: W5P923_SHEEP
Original site: W5P923_SHEEP 
ID   W5P923_SHEEP            Unreviewed;       498 AA.
AC   W5P923;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Glycine receptor beta {ECO:0000313|Ensembl:ENSOARP00000006931.1};
GN   Name=GLRB {ECO:0000313|Ensembl:ENSOARP00000006931.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006931.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000006931.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006931.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000006931.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       {ECO:0000256|RuleBase:RU000687}.
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DR   EMBL; AMGL01038815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01038816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01038817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01038818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01038819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01038820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5P923; -.
DR   SMR; W5P923; -.
DR   STRING; 9940.ENSOARP00000006931; -.
DR   PaxDb; 9940-ENSOARP00000006931; -.
DR   Ensembl; ENSOART00000007037.1; ENSOARP00000006931.1; ENSOARG00000006474.1.
DR   eggNOG; KOG3644; Eukaryota.
DR   OMA; KFFWGIL; -.
DR   Proteomes; UP000002356; Chromosome 17.
DR   Bgee; ENSOARG00000006474; Expressed in cerebellum and 19 other cell types or tissues.
DR   ExpressionAtlas; W5P923; baseline.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016934; F:extracellularly glycine-gated chloride channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   CDD; cd19010; LGIC_ECD_GlyR_beta; 1.
DR   CDD; cd19061; LGIC_TM_GlyR_beta; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR008060; Glycine_rcpt_B.
DR   InterPro; IPR047031; GlyR_beta__ECD.
DR   InterPro; IPR047029; GlyR_beta_TM.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   NCBIfam; TIGR00860; LIC; 1.
DR   PANTHER; PTHR18945:SF29; GLYCINE RECEPTOR SUBUNIT BETA; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR01677; GLYRBETA.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|RuleBase:RU000687};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   CHAIN           20..498
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT                   /id="PRO_5022253556"
FT   TRANSMEM        267..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        302..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        333..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        476..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   DOMAIN          58..266
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          274..494
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
SQ   SEQUENCE   498 AA;  56377 MW;  00369C49A620A385 CRC64;
     IKCCITFLFF FFLMTDIFGA SDNIYYFSLL FGKDMLYICL KKQQSAEDLA RVPANSTSNI
     LNRLLVSYDP RIRPNFKGIP VDVVVNIFIN SFGSIQETTM DYRVNIFLRQ KWNDPRLKLP
     SDFRGSDALT VDPTMYKCLW KPDLFFANEK SANFHDVTQE NILLFIFRDG DVLVSMRLSI
     TLSCPLDLTL FPMDTQRCKM QLESFGYTTD DLRFIWQSGD PVQLEKIALP QFDIKKEDIE
     YGNCTKYYKG TGYYTCVEVI FTLRRQVGFY MMGVYAPTLL IVVLSWLSFW INPDASAARV
     PLGIFSVLSL ASECTTLAAE LPKVSYVKAL DVWLIACLLF GFASLVEYAV VQVMLNNPKR
     VEAEKARIAK AEQADGKGGN VAKKSTVNGA GTPVHISTLQ VGETRCKKVC TSKSDLRSND
     FSIVGSLPRD FELSNYDCYG KPIEVNNGLG KSQAKNNKKP PPAKPVIPTA AKRIDLYARA
     LFPFCFLFFN VIYWSIYL
//
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