ID W5P923_SHEEP Unreviewed; 498 AA.
AC W5P923;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Glycine receptor beta {ECO:0000313|Ensembl:ENSOARP00000006931.1};
GN Name=GLRB {ECO:0000313|Ensembl:ENSOARP00000006931.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000006931.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000006931.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000006931.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000006931.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; AMGL01038815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01038816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01038817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01038818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01038819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01038820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5P923; -.
DR SMR; W5P923; -.
DR STRING; 9940.ENSOARP00000006931; -.
DR PaxDb; 9940-ENSOARP00000006931; -.
DR Ensembl; ENSOART00000007037.1; ENSOARP00000006931.1; ENSOARG00000006474.1.
DR eggNOG; KOG3644; Eukaryota.
DR OMA; KFFWGIL; -.
DR Proteomes; UP000002356; Chromosome 17.
DR Bgee; ENSOARG00000006474; Expressed in cerebellum and 19 other cell types or tissues.
DR ExpressionAtlas; W5P923; baseline.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016934; F:extracellularly glycine-gated chloride channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19010; LGIC_ECD_GlyR_beta; 1.
DR CDD; cd19061; LGIC_TM_GlyR_beta; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR008060; Glycine_rcpt_B.
DR InterPro; IPR047031; GlyR_beta__ECD.
DR InterPro; IPR047029; GlyR_beta_TM.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF29; GLYCINE RECEPTOR SUBUNIT BETA; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01677; GLYRBETA.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 20..498
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022253556"
FT TRANSMEM 267..290
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 302..321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 333..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 58..266
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 274..494
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 498 AA; 56377 MW; 00369C49A620A385 CRC64;
IKCCITFLFF FFLMTDIFGA SDNIYYFSLL FGKDMLYICL KKQQSAEDLA RVPANSTSNI
LNRLLVSYDP RIRPNFKGIP VDVVVNIFIN SFGSIQETTM DYRVNIFLRQ KWNDPRLKLP
SDFRGSDALT VDPTMYKCLW KPDLFFANEK SANFHDVTQE NILLFIFRDG DVLVSMRLSI
TLSCPLDLTL FPMDTQRCKM QLESFGYTTD DLRFIWQSGD PVQLEKIALP QFDIKKEDIE
YGNCTKYYKG TGYYTCVEVI FTLRRQVGFY MMGVYAPTLL IVVLSWLSFW INPDASAARV
PLGIFSVLSL ASECTTLAAE LPKVSYVKAL DVWLIACLLF GFASLVEYAV VQVMLNNPKR
VEAEKARIAK AEQADGKGGN VAKKSTVNGA GTPVHISTLQ VGETRCKKVC TSKSDLRSND
FSIVGSLPRD FELSNYDCYG KPIEVNNGLG KSQAKNNKKP PPAKPVIPTA AKRIDLYARA
LFPFCFLFFN VIYWSIYL
//