ID W5PA60_SHEEP Unreviewed; 1813 AA.
AC W5PA60;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
GN Name=PLXNB3 {ECO:0000313|Ensembl:ENSOARP00000007319.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007319.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000007319.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007319.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000007319.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AMGL01116854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01116855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5PA60; -.
DR STRING; 9940.ENSOARP00000007319; -.
DR PaxDb; 9940-ENSOARP00000007319; -.
DR Ensembl; ENSOART00000007428.1; ENSOARP00000007319.1; ENSOARG00000006822.1.
DR eggNOG; KOG3610; Eukaryota.
DR HOGENOM; CLU_001436_1_1_1; -.
DR OMA; LCYTTGG; -.
DR Proteomes; UP000002356; Chromosome X.
DR Bgee; ENSOARG00000006822; Expressed in vas deferens and 21 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd12791; RasGAP_plexin_B3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF33; PLEXIN-B3; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1157..1177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..257
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 141..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1813 AA; 196900 MW; 084443A5067EEDD0 CRC64;
FSSEGLGRLV VGDLSDYNNS YVAALANAQS AYFVFRRRGD QAQAEYRSYV ARVCLRDANL
YSYVEVPLSC RGHGLVQAAA LAPGALLGAF AAGLRGVQAA LCAFPLAELD ASMERARRLC
YTAGVSPCHP PEPRLSQVVL ANSSSPPQDS PESYPCGDEH TPSPIAGRQP VEARPLLQLK
HSISAVAALQ ADGHTIAFLG DVRGQLHKVF LNGTQGQVYH SQQVGTPGSA ISPDLLVDSS
GSHLYVLTSQ QVARVPVAAC PQLLDCSSCL QAQDPLCGWC VLQGRCTRKS QCRRATQPNQ
WLWTYEDGLC LHIQSVLPAH HPRQEQGQVT LLVPRLPTLA MDEYFHCAFG NYDSLAHVEG
PQVACVTPPQ DQLPLNPPGT DHITLSLALM FEDVPVAATN FSFYDCSAVT ALEAAAPCRA
CVGSLWRCHW CPQASHCVHG EHCPEGERTI YSTQEVGGST LPHAPPAPRP LAFQSAKRSP
PARWTSRCVA RGLVRCPPFA ASGLGEPFGP PRAEPSAFPG EHSSRWGPGI ADGVQATDSI
HPPGLACLLP LLARAARTTA EAASVPGGGG WGLGPHSLPG PAGRCPIPQS HLPLDTSCRL
GLSQALRDSL TPFNPLSLMR PALGTPRLGD VPCTGWGWGG IPVGRLPRGG GQGSWEVLSC
VGPDPPFHPQ FHPPIFQQEL PVPIYVTRGE GQRLDNAHSL HVTLYDCAVG HPDCSHCQAA
NGSLGCLWCS HGQPACRYGP LCPPGAVEPL CPTPRIETVE PLTGPPEGGL VLTIQGSNLG
RDFADVQDAV SVAGWPCRPE PSLYRISTRI VCVTSPAPNR TMGPIQVAIK GRPPGISTQY
FTYQDPVLLS LSPQRGPQAG GTQLTIHGQR LQTGGNISAF VGSQPCPIQE PVCPEAIVCH
TMPQASPGDA VVRVVFGQAQ RLLLASPFHY TANPQLVAAE PSVSFRGGGR LIRVRGTGLD
VVQQPLLSVC KGSGQAGSPQ LTSPRPAPSQ CSSVCSINSS TLLLCRSPAV PDTASPRRVF
FSLDNVHVDF ASASGGQDFL YQPNPRSQQS WGTGGTCRHR LSDSTQGEGL NLAISKEEVR
VHIGDSECLV KTLTLTHLYC EPPPQVPQPS NGTLLQFVES CASHHPQVQM GNVRLVLGPV
QYEAEPVLSA FPVEAQVGLG VGAALLITAV LLLTLMYRHK SKQAMRDYQK VLMQLENLEI
GVGDQCRKEF TDLMTEMTDL SSDLEASGIP FVDYRTYAER VLFPGRNSGT LQPAVEGPGE
EGRRAPVHQG LMQLSNLLNS KLFLLTLIHT LEGQPSFSQR DRCHVASLLS LALHSKLEYL
TEIMRTLLSD LASHYVRKNP KLMLRRTETM AEKLLTNWVS ICLYAFLREV AGEPMYMLLR
AIQYQVDKGP VDAVTGKAKR TLNDSRLLRE DVEFRALTLM VLASPGPGGP SRSNTALHIP
TRVLDTDTIT QVKEKVLDQI YKGTPFSQRP SAHALDLEWR SGLAGHLTLS DEDVTSVTQN
RWKRLNTLQH YKIPDGATVR LIPQLHNGGG IISQSLAPSC PSGENTPMLE DSEEGGVRLW
HLVKAPEEPE AAKARRSSLR DRERERARAK AIPEIYLTRL LSMKGTLQKF VDDAFQAILS
VNRPVPIAVK YLFDFLDELA EKHSIEDPET LHIWKTNSLL LRVWVNTLKN PQLIFDVRVS
DNVDAVLAVI AQTFMDSCTV SEHKVGRDSP VNKLLYAREI PRYKQMVERY YSDIRQSPPA
SYQEMNSALT ELSGNYTSAP HCLQALQELY THIHRYYDQI IGALEEDPVG QKMQLACRLQ
QIAALVENKV TEL
//
