ID W5PAN6_SHEEP Unreviewed; 95 AA.
AC W5PAN6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=High mobility group nucleosome-binding domain-containing protein 3 {ECO:0000256|ARBA:ARBA00022145};
GN Name=HMGN3 {ECO:0000313|Ensembl:ENSOARP00000007497.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007497.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000007497.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007497.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000007497.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to nucleosomes, regulating chromatin structure and
CC consequently, chromatin-dependent processes such as transcription, DNA
CC replication and DNA repair. Affects both insulin and glucagon levels
CC and modulates the expression of pancreatic genes involved in insulin
CC secretion. Regulates the expression of the glucose transporter SLC2A2
CC by binding specifically to its promoter region and recruiting PDX1 and
CC additional transcription factors. Regulates the expression of SLC6A9, a
CC glycine transporter which regulates the glycine concentration in
CC synaptic junctions in the central nervous system, by binding to its
CC transcription start site. May play a role in ocular development and
CC astrocyte function. {ECO:0000256|ARBA:ARBA00025168}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HMGN family.
CC {ECO:0000256|ARBA:ARBA00007696}.
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DR EMBL; AMGL01105597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PAN6; -.
DR STRING; 9940.ENSOARP00000007497; -.
DR PaxDb; 9940-ENSOARP00000007497; -.
DR Ensembl; ENSOART00000007609.1; ENSOARP00000007497.1; ENSOARG00000006997.1.
DR eggNOG; ENOG502S1R1; Eukaryota.
DR HOGENOM; CLU_141985_2_2_1; -.
DR OMA; TVEHSAC; -.
DR Proteomes; UP000002356; Chromosome 8.
DR Bgee; ENSOARG00000006997; Expressed in placental caruncle and 52 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031492; F:nucleosomal DNA binding; IEA:InterPro.
DR InterPro; IPR000079; HMGN_fam.
DR PANTHER; PTHR23087:SF2; HIGH MOBILITY GROUP NUCLEOSOME-BINDING DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR23087; NONHISTONE CHROMOSOMAL PROTEIN HMG; 1.
DR Pfam; PF01101; HMG14_17; 1.
DR PRINTS; PR00925; NONHISHMG17.
DR SMART; SM00527; HMG17; 1.
DR PROSITE; PS00355; HMG14_17; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 95 AA; 10020 MW; 1592DECD1DF02C7A CRC64;
SPENTEGKDG SKVTKQEPTR RSARLSAKPA PPKPEPKPRK TSAKKEPAAK VSKGVKGKKE
EKQDAGKEGP AAPSENGDTK AEEAQKTESV ANEGE
//
