ID W5PAS6_SHEEP Unreviewed; 1260 AA.
AC W5PAS6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSOARP00000007537.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSOARP00000007537.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007537.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000007537.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007537.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000007537.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AMGL01100137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01100142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000007537; -.
DR PaxDb; 9940-ENSOARP00000007537; -.
DR Ensembl; ENSOART00000007650.1; ENSOARP00000007537.1; ENSOARG00000007030.1.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR HOGENOM; CLU_007621_0_0_1; -.
DR OMA; IFFAQIK; -.
DR Proteomes; UP000002356; Chromosome 6.
DR Bgee; ENSOARG00000007030; Expressed in uterus and 50 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1260
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869081"
FT TRANSMEM 288..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 36..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 451..481
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1260 AA; 142485 MW; 1D20A5C1DAFA126B CRC64;
MLSARGPGRA TWVLAGSLLA AALTLPAESR KLDQLPAGRV PLQHPLGPRP LRDPPTAPGV
GPERTAQDLP LGIWPSVENS HVTTPEEAPF RMKFSKEIEV FNPPLASAAS SEPWVHSVFA
FTHSWPRKTL FKRDSAVTHR LYGDISRDVQ GTSENGVIFQ KCAVVSVQSE WPSAHVRLFV
NNTRTPTATN LSDLLLLDNI TGLTVRESVG NQTSRGFQAF RKKFLQVGDS FSVSYTASLE
ARDVRSGDIL LLPAHLSFQS SSPNRTQLRA PFAITAEEKI TVLPNHGLHA AGFCVAFILS
LVLTWAVLFF MVRYQCVKGS SLSRHQVQHH ENKLEHSQFT SADGVNEDLA LNDQMIDILS
SEDPGSMLQA LEELEIATLN RADSDLEACR TQISKDIIAL LLKNLTSSGQ LSPQVERRMG
AVFKKQFLLL EKEIQEEYDR KMVALTAECD LETRKKTESQ YQREMAALEE AEEVLKRVSE
RSAVECSSLL RTLHGLEQEH LRRSLALQQE EDFAKAHRQL AIFQRNELHN IFFTQIKSAI
SKGELKPEAA KMLLQDYSKI QESVEELMDF FQASKRYHLS KRFGHREYLV QNIQSSETRV
QGLLSTASAQ LTLLIQKHER AGYLDEDQMQ VLLERAQTEV FSIKQKLDND LKQEKKKLHQ
KLIIKRRREM LQKHKEQRRE QLSIAEASGA AEEASXAEHS AALGGLQERL DQAALDELRA
LTLSLSEKAT EELRRLQNSG MTQELLKEGE ERDRGQEGVQ SVRQRLKDDA LEASTEEQAE
LRHWEHLIFT KLCSSAFSLS EEELLGMRQE VHGCFAQMDR SLALPKIRAR VLLQRFQTAW
REAEFLKLDQ AVAAPELQPQ SKARKPRSKS RSKIDLLKKC IEDKIQLFKE QAPEDLVEKV
RGELLRERVQ QLEAQEGLFA ESLVSLQFQK AARMARTLWA YTALLSIQDL LLEELSASET
LTKSACMQIL ESHSPELQEL ERKLEDQLAH RQRALDSWQQ WAGEGPGLLQ EPEETDSERQ
VSAVLRRALS KGQKLLEHHQ QSLREEQEDS VVLEDLLENM ETDTFVTLYG QELRLASYLL
KLTMLPGSTL RRLLTVALPA ASQAELLAVL DSVGQKHQDH VVENNGSGVQ ADLGRRGKHQ
GWWQALESKL RGELISRGLE KMLWARKRKE SILKKTCPPL RERVIFSGKG SWPHLSLEST
DELTPVPIVG AEAVDLLNTG EKLFIFRNPK EPEISLRVPP RKKKKNFLNT KKAAWALGMN
//