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Database: UniProt
Entry: W5PB08_SHEEP
LinkDB: W5PB08_SHEEP
Original site: W5PB08_SHEEP 
ID   W5PB08_SHEEP            Unreviewed;       356 AA.
AC   W5PB08;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   SubName: Full=Homeobox B3 {ECO:0000313|Ensembl:ENSOARP00000007619.1};
GN   Name=HOXB3 {ECO:0000313|Ensembl:ENSOARP00000007619.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007619.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000007619.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007619.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000007619.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC       {ECO:0000256|ARBA:ARBA00003263}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family.
CC       {ECO:0000256|ARBA:ARBA00009107}.
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DR   EMBL; AMGL01018481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01018482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01018483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5PB08; -.
DR   SMR; W5PB08; -.
DR   STRING; 9940.ENSOARP00000007619; -.
DR   PaxDb; 9940-ENSOARP00000007619; -.
DR   Ensembl; ENSOART00000007732.1; ENSOARP00000007619.1; ENSOARG00000007106.1.
DR   eggNOG; KOG0489; Eukaryota.
DR   HOGENOM; CLU_051508_1_0_1; -.
DR   OMA; GCAAPQK; -.
DR   Proteomes; UP000002356; Chromosome 11.
DR   Bgee; ENSOARG00000007106; Expressed in epididymis and 50 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45664:SF11; HOMEOBOX PROTEIN HOX-B3; 1.
DR   PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          191..251
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        193..252
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          22..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..96
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   356 AA;  37461 MW;  B1FCA8EAF5596988 CRC64;
     MQKATYYDNT AAALFGGYPS YPGSNGFGYD GPPQPPFQAT THLESDYQRS ACSLQSLGNA
     AAHAKGKELN GSCMRPGLAS EPPPAPPGPP PPTAPTSTTS NSSNAGGPSK SGPPKCGAGS
     NSTLTKQIFP WMKESRQTSK LKNSSPGTEC PLMRRVGAGG RGEGGGGGGG GASRGSGGGG
     GGGDKSPPGS AASKRARTAY TSARLVELEK EFHFNRYLCR PRRVEMANLL NLSERQIKIW
     FQNRRMKWKK DSKMKRHRGG PPRAPRARFG PAPFPVGFSS LDILGARTGA GAPVPHLRQK
     LFPPSSGNLD YNGAPPMAPS QHHGPCDPHP TYTDLSSHHA PPPQGRIQEA PKLTHL
//
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