ID W5PBD1_SHEEP Unreviewed; 706 AA.
AC W5PBD1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=MARCHF7 {ECO:0000313|Ensembl:ENSOARP00000007742.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007742.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000007742.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007742.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000007742.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AMGL01053146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01053147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011991629.1; XM_012136239.2.
DR AlphaFoldDB; W5PBD1; -.
DR SMR; W5PBD1; -.
DR STRING; 9940.ENSOARP00000007742; -.
DR PaxDb; 9940-ENSOARP00000007742; -.
DR Ensembl; ENSOART00000007857.1; ENSOARP00000007742.1; ENSOARG00000007220.1.
DR eggNOG; KOG1609; Eukaryota.
DR OMA; RMMSGNR; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000007220; Expressed in thymus and 53 other cell types or tissues.
DR ExpressionAtlas; W5PBD1; baseline.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd16812; RING_CH-C4HC3_MARCH7; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14471:SF1; E3 UBIQUITIN-PROTEIN LIGASE MARCHF7; 1.
DR PANTHER; PTHR14471; MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER; 1.
DR Pfam; PF12906; RINGv; 1.
DR SMART; SM00744; RINGv; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51292; ZF_RING_CH; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 541..611
FT /note="RING-CH-type"
FT /evidence="ECO:0000259|PROSITE:PS51292"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 78068 MW; 6588627814B8AE4F CRC64;
MESKPSRIPR RISVQPASSL SARLMSGSRG SGLNDTYHSR DSSFRLDSEY QSASAAASPF
QPTWYSESEI TQGARSRSQN QQRDHDSKRP KLSCTNCTST STGRSIGHGL NAVSDSTWRH
SQVPRSSSVV LGSFGTDLMR ERRTDSSISN LADYSHRSGD FTTSSYVQDR VPSSYSQGAR
PKENSLSTLQ LSTSSTNHQM PSEHQTIPCS RDSARNSLRS NFSSRELESP QSSMQPGFSY
TSNRGEPSTI GSSDRINSSH RSFQESSDNE GRRTTRRLLS RIASSMSSTF FSRRSNQESL
NTRSLGSENS YVSPRILTGS QSRGNAASAS DIPDNRASEA SQGFRFLRRR WGLSSLSQNH
NSEPDSQNFN QESEGRNTGP WLSSSLRNRC TPLFSRRRRE GRDESSRIST SDIPSRSHHL
FRRESNEVVH LEAQSDPLGA SANRPQASAA PSSVGTGDSP SDSTRSGRST GITGILPGSL
FRFAVPPALG NNLTDNVMIT VDIIPSGWSS SDGKNDKTKN VPSRDPERLQ KIKESLLLED
SEEEEGDLCR ICQMAAASSS NLLIEPCKCT GSLQYVHQEC MKKWLQAKIN SGSSLEAVTT
CELCKEKLQL NLEDFDIHEL HRARANEQAE YEFISSGLYL VVLLHLCEQS FSDMIGNTNE
PSTRVRFINL ARTLQAHMED LESPHGPLIG SQLRQQLQSL KITFQL
//
