ID W5PBV9_SHEEP Unreviewed; 2467 AA.
AC W5PBV9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Dopey N-terminal domain-containing protein {ECO:0000259|Pfam:PF04118};
GN Name=DOP1A {ECO:0000313|Ensembl:ENSOARP00000007920.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000007920.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000007920.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000007920.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000007920.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dopey family.
CC {ECO:0000256|ARBA:ARBA00008395}.
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DR EMBL; AMGL01105774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000007920; -.
DR PaxDb; 9940-ENSOARP00000007920; -.
DR Ensembl; ENSOART00000008037.1; ENSOARP00000007920.1; ENSOARG00000007379.1.
DR eggNOG; KOG3613; Eukaryota.
DR HOGENOM; CLU_001045_0_0_1; -.
DR OMA; LHHGCNF; -.
DR Proteomes; UP000002356; Chromosome 8.
DR Bgee; ENSOARG00000007379; Expressed in testis and 55 other cell types or tissues.
DR ExpressionAtlas; W5PBV9; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0006895; P:Golgi to endosome transport; IEA:InterPro.
DR InterPro; IPR040314; DOP1.
DR InterPro; IPR007249; Dopey_N.
DR PANTHER; PTHR14042; DOPEY-RELATED; 1.
DR PANTHER; PTHR14042:SF22; PROTEIN DOPEY-1; 1.
DR Pfam; PF04118; Dopey_N; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 11..297
FT /note="Dopey N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04118"
FT REGION 582..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1169..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2467 AA; 276647 MW; EA57A7BA65BB9D76 CRC64;
MNTEELELLS DSKYRNYVAA VDKALKNFEY SSEWADLISA LGKLNKVLQN NAKYQVVPKK
LTIGKRLAQC LHPALPGGVH RKALETYEII FKIIGPKRLA KDLFLYRNSS GLFPLLANAA
MSVKPTLLSL YEIYYLPLGK TLKPGLQGLL TGILPGLEEG SEYYERTNTL LEKVAAAVDQ
SAFYSALWGS LLTSPAVRLP GITYVLAHLN RKLSMEDQLY IIGSDIELMV EAVSTSVQDS
SVLVQRSTLD LILFCFPFHM SQATRPDMIR ILSAALHVVL RRDMSLNRRL YAWLLGFDNN
GAIIGPRSTR HSNPEEHATY YFTTFSKDLL VQAMVGILQV NLFGEESTLM QDLKPFRILI
SLLDKPELGP VILEDVLIEV FRTLYSQCKA ELDLQMEPPF SKDHAQLSSK LRENKKTAEL
IKTANLLFNS FEPYYMWDYV ARWFEECCRR TLHARLQTGP GDSSESSELQ LTSFCLLVDF
LLDIVSLPTR SMRVLCQETY IEIQTEHLPQ LLLRMISALT SHLQTLHLTE LTDSLRLCSK
ILSKVQPPLL SASTGGVLQF PSGQNNSVKE WEDKKVSSVS LENPTEVFED GENPPSSRSS
ESGFTEFIQY QADRTDDIDR ELSEGQGAAA IPIGSTSSET ETASTVGSEE TIIQPPSIIA
QGAAPRSGKT AQKTAMQCCL EYVQQFLTRL INLYIIQSSA FSQALTPEHQ GDLSGEQGEI
SNWDRDSQGD VKERNISKQK TSKEYLSAFL AACQLFLECS SFPVYIAEGN HTSDLRSEKS
DTDWEHVQPP LWLQTLMSAC SQASDFSVQS VAISLVMDLV GLTQSVAVVT GENINSVEPA
QPLSPNQGRV AVVIRPPLTP GNLRYIAEKT EFFKHVALTL WNQLGDATPQ HHQKSVELFY
QLHNLVPSSS ICEDVISQQL THKDKKIRME AHAKFAVLWH LTRDLHINKS SSFARSFDRS
LFIMLDSLNS LDGSTSSVGQ AWLNQVLQRH DIARVLEPLL LLLLHPKTQR VSVQRVQAER
YWNKAPCFPG EESDKHFMQS FSCNNVSQVQ LMASKGNGEK TLTMDEMENF SLTVNPLSDR
LSLLSTSSET IPMVVSDFDL PDQQIEILQR SDSGCSQSSA GDNLSYEADP ESVTAQDDSQ
APSAGSPDDD VQQVVFDLIC KVVSGLEAES ASVPSQSEME GLPPKDSDVD PGEEVTSNED
QPAQQSQSAL LNNDGSQFLS VSAEGSCECM PNGISRNSSS PCISGTAQTF HDSSVASTET
RCRQRSHSSI QFSFKEKLSE KVSEQETIVK ESGKQPGAKP KVKLARKKDD DKKKTSNEKP
KQTSVFFSDG LDLENWYSCG EGEISEIESD MGSPGSRKSP NFNIHPLYQH VLLYLQLYDS
SRTLYAFSAI KAVLKTNPIA FVNAISTTSV NNAYTPQLSL LQNLLARHRI SVMGKDFYSH
IPVDSNHNFR SSMYIEILIS LCLYYMRSHY PTHVKVSAQD LMGNRNMQMM SIEILTLLFT
ELAKVIESSA KGFPSFISDM LSKCKVQKVI LHCLLSSIFS AQKWHSEKLA GKNMIAVEEG
FSEDSLINFS EDEFDNGSTL QSQLLKVLQR LIVLEHRVMT IPEENETGFD FVVSDLEHIS
PHQPMTSLQY LHAQPITSQG MFLCAVIRAL HQHCACKMHP QWIGLITSTL PYMGKVLQRV
VVSVTLQLCR NLDNLIQQYK YETGLSDSRP LWMASIIPPD MILTLLEGIT AIIHYCLLDP
TTQYHQLLVN VDHKHLFEAR SGILSILHMI MSSVTLLWSV LHQADSSEKT TIAASASVTT
INLGATKNLR QQILELLGPI SMNHGVHFMA AIAFVWNERR QNKAPTRTKV IPAASEEQLL
LVELVRSISV MRAETVIQTV KDVLKQPPAI AKDKKHLSLE VCMLQFFYAY IQRIPVPNLV
DSWASLLILL KDSIQLSLPA PGQFLILGVL NEFIMKNPSL ENKKDQRDLQ DVTHKIVDAI
GAIAGSSLEQ TTWLRRNLEV KPSPKIMVDG TNLESDVEDM LSPAVGTSDI TPSVYSVHAL
ALLSEVLAHL LDMVFYSDEK ERVIPLLVNI MHYVVPYLRN HSAHNAPSYR ACVQLLSSLS
GYQYTRRAWK KEAFDLFMDP SFFQMDASCV NHWRAIMDNL MTHDKTTFRD LMTRVAVAQS
SSLNLFANRD VELEQRAMLL KRLAFAIFSS EIDQYQKYLP DIQERLVESL RLPQVPTLHS
QVFLFFRVLL LRMSPQHLTS LWPTMITELV QVFLLMEQEL TADEDISRTS GPSVAGLETT
YTGGNGFSTS YNSQRWLNLY LSACKFLDLA LALPSENLPQ FQMYRWAFIP EVSDDSGLEV
RRQGIHQREF KPYVVRLAKL LRKRAKKNPE EDNSGRALGW EPGHLLLTIC TVRSLEQLLP
FFNVLSQVFN SKVTSRCAGH SGSPVLYSTT FPNKDMKLEN HKPFSSKARQ KIEEMVEKDF
LEGVVKT
//
