ID W5PCD9_SHEEP Unreviewed; 995 AA.
AC W5PCD9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=HELP domain-containing protein {ECO:0000259|Pfam:PF03451};
GN Name=EML4 {ECO:0000313|Ensembl:ENSOARP00000008101.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008101.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000008101.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008101.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000008101.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; AMGL01077890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01077891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PCD9; -.
DR SMR; W5PCD9; -.
DR STRING; 9940.ENSOARP00000008101; -.
DR PaxDb; 9940-ENSOARP00000008101; -.
DR Ensembl; ENSOART00000008222.1; ENSOARP00000008101.1; ENSOARG00000007545.1.
DR eggNOG; KOG2106; Eukaryota.
DR HOGENOM; CLU_011754_0_1_1; -.
DR OMA; FTYNDSH; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000007545; Expressed in duodenum and 55 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR CDD; cd21950; TD_EMAP4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF11; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 242..310
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 519..551
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 602..634
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 731..772
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 844..878
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 97..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 31..65
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 124..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..958
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 995 AA; 110301 MW; 4296E3BFCBE6A0E8 CRC64;
MEDSLPSLAS VCGSSTLSNF CADDSISAAS TSDVQDRLSA LELRVQQQED EITVLKAALA
DVLRRLAISE DHVASVKKSV PSKGNPGLRE AISMSCITNG SGTNRKPSHT SSVSIARKET
LSSAAKSGTE KKKEKPQGQR EKKEDSHSND QSPQIRASPS PQPSSQPLQI HRQTQESKNS
TPTKSIKRPP TAEKSHNSWE NSDDSRNKLL RAVSTSKLIS KVIKNTDKHK DVIINQEGEY
IKMFMRGRPI TMFIPSDVDN YDDIRTELPP EKLKLEWVYG YRGKDCRANV YLLPTGEIVY
FIASVVVLFN YEERTQRHYL GHTDCVKCLA IHPDKIRIAT GQIAGVDKDG RPLQPHVRVW
DSVSLSTLQI IGLGTFERGV GCLDFSKADS GVHLCVIDDS NEHMLTVWDW QKKSKGAEIK
TTNEVVLAVG FHPTDANIII TCGKSHIFFW TWSGNSLTKK QGVFGKYEKP KFVQCLAFLG
NGDVLAGDSG GVILIWSKTT VEPTPGKGPK GVYQISKQIK AHDGSVFTLC QMRNGMLLTG
GGKDRKIILW DHDLNPEREI EVPDQYGTIR AVAEGKADQF LVGTSRNFIL RGTFNDGFQI
EVQGHTDELW GLATHPFKDL LLTCAQDRQV CMWNSVEHRL EWTRLVDEPG HCADFHPSGT
VVAIGTHSGR WFVLDAETRD LVSIHTDGNE QLSVMRYSVD GTLLAVGSHD NFIYLYAVSE
NGRKYSRHGK CTGHSSYITH LDWSPDNKYI MSNSGDYEIL YWDIEHGCKL MRNRSECKDI
NWTTYTCVLG FQVFGVWPEG SDGTDINALV RSHNRKVIAV ADDFCKVHLF QYPCSKAKAP
SHKYSAHSSH VTNVSFTHND SHLISTGGKD MSIIQWKLVE KLPLPQNETL ADPTLTKAPP
SSIESVVQSD TPTPPPSQPL NETAEEESRI SSSPTLLENS LEQTVEPSED HSEEQSEGGS
EELGEPVYEE LANKLSEEQS RAALPGGQQD PSSLS
//
