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Database: UniProt
Entry: W5PCV9_SHEEP
LinkDB: W5PCV9_SHEEP
Original site: W5PCV9_SHEEP 
ID   W5PCV9_SHEEP            Unreviewed;      3334 AA.
AC   W5PCV9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   03-JUL-2019, entry version 45.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000008271};
GN   Name=LAMA3 {ECO:0000313|Ensembl:ENSOARP00000008271};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008271, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000008271, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008271};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000008271}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AMGL01066575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01066576; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01066577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01066578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004020671.1; XM_004020622.3.
DR   STRING; 9940.ENSOARP00000008271; -.
DR   Ensembl; ENSOART00000008393; ENSOARP00000008271; ENSOARG00000007694.
DR   CTD; 3909; -.
DR   GeneTree; ENSGT00940000155638; -.
DR   OMA; WVAPPSY; -.
DR   OrthoDB; 2342at2759; -.
DR   Proteomes; UP000002356; Chromosome 23.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005610; C:laminin-5 complex; IEA:Ensembl.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR   GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR009254; Laminin_aI.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR000034; Laminin_IV.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00052; Laminin_B; 1.
DR   Pfam; PF00053; Laminin_EGF; 13.
DR   Pfam; PF00054; Laminin_G_1; 1.
DR   Pfam; PF02210; Laminin_G_2; 4.
DR   Pfam; PF06008; Laminin_I; 1.
DR   Pfam; PF06009; Laminin_II; 1.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00180; EGF_Lam; 14.
DR   SMART; SM00281; LamB; 1.
DR   SMART; SM00282; LamG; 5.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF49899; SSF49899; 5.
DR   PROSITE; PS01248; EGF_LAM_1; 3.
DR   PROSITE; PS50027; EGF_LAM_2; 12.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR   PROSITE; PS51115; LAMININ_IVA; 1.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32   3334       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004869158.
FT   DOMAIN       38    293       Laminin N-terminal. {ECO:0000259|PROSITE:
FT                                PS51117}.
FT   DOMAIN      294    350       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      351    420       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      421    464       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      487    531       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      532    584       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      627    679       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      680    724       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1265   1310       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1355   1403       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1404   1454       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1475   1652       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN     1686   1732       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1733   1785       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     2389   2590       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2597   2759       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2766   2926       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     2987   3151       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     3158   3331       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   COILED     1880   1914       {ECO:0000256|SAM:Coils}.
FT   COILED     1922   1942       {ECO:0000256|SAM:Coils}.
FT   COILED     1991   2082       {ECO:0000256|SAM:Coils}.
FT   COILED     2134   2168       {ECO:0000256|SAM:Coils}.
FT   COILED     2178   2198       {ECO:0000256|SAM:Coils}.
FT   COILED     2338   2358       {ECO:0000256|SAM:Coils}.
FT   COILED     2362   2382       {ECO:0000256|SAM:Coils}.
FT   DISULFID    316    325       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    388    397       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    440    449       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    487    499       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    507    516       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    532    544       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    534    551       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    553    562       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    650    659       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    680    692       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    682    699       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    701    710       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1265   1277       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1267   1284       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1286   1295       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1379   1388       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1404   1416       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1406   1423       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1425   1434       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1705   1714       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1733   1745       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1756   1765       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   3334 AA;  367162 MW;  499FBAF5077B5654 CRC64;
     MAAAGRARDW APGSVLPLLS LLLVQAGCAA ARHPPAPARL SLHPPYFNLA EAARIWATAT
     CGEREPGGAR PRPELYCKLV GGPTAPGSGR TIQGQFCDYC NSEDPRKAHP VTNAIDGSER
     WWQSPPLSSG MQYNKVNVTL DLGQLFQVAY VLIKFANSPR PDLWVLERSV DFGSTYSPWQ
     YFAHSKVDCL EQFGQEANRA VTQDDDVLCT TEYSRIVPLE NGEVVVSLIN GRPGAKNFTF
     SHTLREFTKA TNIRLRFLRT NTLLGHLISK AQRDPTVTRR YYYSIKDISI GGRCVCNGHA
     EVCNANNPEK LFRCECQHNT CGETCDRCCT GYSQRRWRPA TGKQSNECEA CNCHGHSTDC
     YYDPDVERQQ ASLNIQGLYA GGGVCINCQH NTAGVNCEKC AKGYYRPYGI PVHAPDGCIP
     CSCHPERAED CEQGSGRCTC RPNFRGDHCE ECAAGYYHFP VCSRIPILPI STPSPEDPVA
     GDIIKGCDCN LEGVLPEICD AQGRCLCRTS VGGARCDACR SGFYSFPICQ ACQCSALGSY
     QTPCSPVTGQ CECRPGITGQ QCDRCLSGAS DFPYCQGSSN VCDPAGTVDS SLGHCQCKLH
     VESPSCSLCK PLYWNLAKEN PDGCSECRCH MAGTMSGIGE CGQLDGDCHC KSHVGGDSCD
     TCEDGYFALE KSNYFGCQGC RCDIGGAVTP VCSGPSGVCQ CREHVVGKSC QRPENNYYFP
     DLHHMKYEIE DGTTPSGRAL RFGFDPLEFP EFSWRGYAQM TPVQNEVRIM LNVGKSSLSL
     FHVVLRYMNP GTEAVSGRIT IYPSWAKAGA AQSKEIRFQP SKEPAFVTVP GNGFADPFSI
     VPGTWIACIK VEGVLLDYLV LLPRDYYEAP LLQLPVTEPC ANVGHPQENC LLYQHLPVTR
     FPCALACEAR HFLLDGEPRP LAVRQPTPAH PVMVDLSGRE VELHLRLRVP RVGRYVIMVE
     YAAEADQLSE AAVHVQSPGA DLAGWVDIYS CKYCVLCRSA VTDGRGRLAV YELLADVDVR
     LRARMAQFLL HQVCIIPTEE FSTEYLRPHV KCIASYGRFV NQSASCVSLV PETPPTALIL
     DVPTGGSSPR LPEDPSPPAD AVLGVTLKAP QTQVTLQGLV PRPGRYVIVV HFYQPAHPAF
     PAQVSVDGGR LQAGVFRASF CPHVLGCRDQ VITGDQVEFD ISEPEVSLTV TVPEGKSLVL
     VRVLVVPAEN YDYQILHRKS LDKSLEFVTN CGGDSFYIDP QRASEFCKNS ARSLVALYHE
     GALPCECHPA GAIGHPCSPE GGQCPCRPHV IGRQCTRCQT GFYEFPHCKP CNCGRRLCEE
     TTGRCLCPPR TVRPQCDMCE VRSFSFHPLA GCEGCNCSRM GTDRAATVEC DRDHGQCRCK
     PRITGRQCDR CTPGFYRFPE CLPCHCSRDG TEPGVCDPGT GACLCKENVQ GTECNMCREG
     SFYLDPANPK GCTSCFCFGV SHHCHSTHKR RAKLVDMMGW RLQTADGVDI PVSFNPGSSS
     MVADLQELPA TVHSASWVAP PSYLGDKVSS YGGYLTYQIK SFGLPADMVP LERKPAVQLI
     GQHMSVIYHE PNHPRPDRLH HGRVQMVEGN FRHASSHAPV TREELMTVLS RLQGVHLRGL
     YFTETQRLTL SGVGLEEASE AGSGRRAKSV EMCACPPDYT GDSCQGCSPG YYRENKGLYT
     GRCVPCNCNG HSNRCQDGSG VCINCQHNTA GEHCERCKEG YYWNTVHASC RVCPCPHSDS
     FATGCVVTGE NVKCFCKPGY TGTRCERCAP GYFGNPQKFG GSCQPCNCNS NGQLGSCDPL
     NGDCISQEPK DGGPGEECDD CDSCVMTLLN DLATMDDELR LVKSQLQGLS VSAGTLEQIR
     RLETQTKDLR NQLLSYRPTI SNHKSKMDGL EKELSNLNRE FETLQEKVQI NSRKAQTLYN
     NIDQTTQSAK ELDSKIKNVI RNVHILVKQI SGTEGDGNRV PSGDFSRELA EAGRMMRELR
     TRNFGKHLRD AEAERREAQQ LLNRIRSWLE NHQVENNGLA KNIQDALNDY EAKLSGLRAA
     LQEASTQAKQ ATGLNRENEK ALESLKRQVK EMNSLQSDFT KRLATADSSL MQTNNVLQLM
     KKSHEEYEKS AVTLNEVRHE LSDKVRELSR SASRASLVEE AERHSQSLQE LAKQLEEIKR
     NASGDELVRC AVDAATAYEN ILNAIKAAED AADKATTASE AALQTVIKED LPRKAKTLSS
     NSDKLLNEAK ITQQKLQQEI SPALNNLQQT LKTMTVQKGL IDTNLTSIRG DLHGIQRDDI
     DGIINSAKSL VRNANDITNE VLDGLNPIQT DVERIKDTYS STQSEDFNKA LSDADNSVKK
     LTNKLPDLLS KIESINQQLL PLGNISDNVD RIRELIQQAR DAANKVAVPM RFNGRSGVEV
     RLPNDLEDLK GYTSLSLFLQ RPESTETGGT ENMFVMYLGN KDASRDYIGM AVVDGQLTCV
     YNLGEDEAEL QVDQTLTQSK TQEAVMDRVK FQRIYQFARL NYTLKATSSK PETHQFHDMD
     SGNSNTLLNL DPENAVFYVG GYPSDFRPPS RLRFPPYKGC IELDDLNENV LSLYNFKKTF
     NLNTTEVEPC RRRKEESDKN YFEGTGYARV PTQPNAPFPT FGQTIQTTVD RGLLFFAENQ
     DHFISLDVED GRLMVRYKLN SEPPKEKGIR DIINDGKDHL IQIKIGKVQQ RMWINVDIQS
     VKIEDDIFDF STYYLGGIPI SIRERFNIST PAFRGCMKNL KKTTGVVRLN DTVGVTKKCS
     EDWKLVRSAS FSRGGQLSFT NLDFPSSSHF QASFGFQTFQ PSGILLSHQT GASSVQVTLE
     DGHIELSTRD SSSPIFTSPQ TYMDGLLHYV SVISDNSGLR LLIDDQPLKN NQRLRGLSDF
     QQSLRLGGSH FEGCISNVFI QRSSESPEVL DLASKSSKRD VSLGFCSLNE PPFLMLLKGS
     TRFYKAKTFS IHQPLQDAPA ISPRSSKAWR EAQSCPPLPG IQTSHRAVRF GDSPTSHLLF
     MLPQELLKPR SQFAVDVLTT ASRGLVFYTG TRSSFMALYL SKGRLVFALG AEGKKLKLKS
     REKCSDGKWH TVTFGQDGGK GRMVVDGLRT REGRLPGNST ISLRAPVYLG SAPSGKPKSL
     PQNSFVGCLR NFQLDLKPLE TPSASFGVSP CLGGSLEKGI YFSQEGGHII LANSVSLGPE
     FKLVFSIRPR SLTGILIHIG SQPGEHLGVY MEAGKVTASV GSEAGGVLTS VTPKQALCDG
     QWHSVAVTIK QHILHLKLDA DDSYTAGRHP FPPARPLERL YIGGVPGNLK TPKLPVWTSF
     FGCLKNIQVN HIPVPVTGAA EVQGTVSLNG CPDH
//
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