ID W5PDA2_SHEEP Unreviewed; 301 AA.
AC W5PDA2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=GTP-binding protein {ECO:0000256|PIRNR:PIRNR038017};
GN Name=GEM {ECO:0000313|Ensembl:ENSOARP00000008414.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008414.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000008414.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008414.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000008414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with Calmodulin. {ECO:0000256|PIRNR:PIRNR038017}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. RGK family.
CC {ECO:0000256|ARBA:ARBA00008846, ECO:0000256|PIRNR:PIRNR038017}.
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DR EMBL; AMGL01112778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PDA2; -.
DR SMR; W5PDA2; -.
DR STRING; 9940.ENSOARP00000008414; -.
DR PaxDb; 9940-ENSOARP00000008414; -.
DR Ensembl; ENSOART00000008536.1; ENSOARP00000008414.1; ENSOARG00000007839.1.
DR eggNOG; KOG0395; Eukaryota.
DR HOGENOM; CLU_041217_3_2_1; -.
DR OMA; SNEYNPQ; -.
DR Proteomes; UP000002356; Chromosome 9.
DR Bgee; ENSOARG00000007839; Expressed in mitral valve and 51 other cell types or tissues.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR CDD; cd04148; RGK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR017358; RGK.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45775:SF4; GTP-BINDING PROTEIN GEM; 1.
DR PANTHER; PTHR45775; RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C; 1.
DR Pfam; PF00071; Ras; 1.
DR PIRSF; PIRSF038017; GTP-binding_GEM; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|PIRNR:PIRNR038017};
KW GTP-binding {ECO:0000256|PIRNR:PIRNR038017};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR038017};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 301 AA; 34114 MW; 87E01AD72306D10D CRC64;
ATLLNMEVPI SPGPIQPGPD DEQQRWSIPA DGRHLMVQKE PPQYGQRSRP PTAPEDPCRR
SWSSDSTDSV ISSESGNTYY RVVLIGEQGV GKSTLANIFA GVHDSMDSDC EVLGEDTYER
TLMVDGEIAT IILLDMWENK GESEWLQDHC MQVGDAYLIV YSITDRASFE KASELRIQLR
RARQTEDIPI ILVGNKSDLV RCREVSVSEG RACAVVFDCK FIETSAAVQH NVKELFEGIV
RQVRLRRDSK EKKNGRRLAY QKRRESIPRK ARRFWGKIVA KNNKNMAFKL KSKSCHDLSV
L
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