ID W5PDR5_SHEEP Unreviewed; 587 AA.
AC W5PDR5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=MACPF domain-containing protein {ECO:0000259|PROSITE:PS51412};
GN Name=C8A {ECO:0000313|Ensembl:ENSOARP00000008579.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008579.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000008579.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008579.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000008579.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; AMGL01001715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01001716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004002064.1; XM_004002015.3.
DR AlphaFoldDB; W5PDR5; -.
DR SMR; W5PDR5; -.
DR STRING; 9940.ENSOARP00000008579; -.
DR PaxDb; 9940-ENSOARP00000008579; -.
DR Ensembl; ENSOART00000008704.1; ENSOARP00000008579.1; ENSOARG00000007993.1.
DR eggNOG; ENOG502QT87; Eukaryota.
DR HOGENOM; CLU_032453_1_0_1; -.
DR OMA; CQPGVTI; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000007993; Expressed in liver and 3 other cell types or tissues.
DR ExpressionAtlas; W5PDR5; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF1; COMPLEMENT COMPONENT C8 ALPHA CHAIN; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane {ECO:0000256|ARBA:ARBA00022452};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022452};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..587
FT /note="MACPF domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869195"
FT DOMAIN 139..501
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT REGION 565..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 99..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 118..133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 587 AA; 66418 MW; E05A2C377A8B472B CRC64;
MFAAAFFLLF LMTCQPGVTI QEKVNWRVSR AVESFTPTAV SCQLDNWAEW TDCFPCQDKK
YRYRSLLQPN KFGGTICSGN VWDQASCHSP TACLSQAQCG QDFQCKETGR CLKRHLVCNG
DQDCLDGSDE DDCEDFRIPE NDCSQYDPIP GSERAALGYN ILTQEETQNV YDARYYGGQC
ETVYNGEWRE LQYDPACERL YYGDDDKYFR KPYNFLKYHF EALADTKFSS EKYNDVNDLL
TKVKNDNSVS KGLTVGVSST RNPVMVTIGV STSQDASFLK KLSKYNEKKY IFMRIFTKVQ
TAHFKMRREN IMLDEGMQQS LMELPEQYHY GIYAKFINDY GTHYITSGSM GGVYEYILVL
NREKMETAGI TSTEIKRCFG VSLGIEYSEK IQTRGSLSLG PCEKSGDGKL TEDQKAMGME
DFISRVRGGS SGWGGGLTQE SSIITYRSWG RSLKYNPAVI DFEIRPIHEI LRHTNLGSLE
TKRQNLRRAL DQYLMEFNAC RCGPCFNNGE PILEGTSCKC LCPVGRQGLA CEQMQSEGAK
ADGHWSCWSS WSACRSGTQE RRRECNNPAP QNGGASCPGH RVQTQAC
//
